Wnt/β-catenin signaling

被引：292
作者：
Akiyama, T [1 ]
机构：
[1] Univ Tokyo, Inst Mol & Cellular Biosci, Lab Mol & Genet Informat, Bunkyo Ku, Tokyo 1130032, Japan
来源：
CYTOKINE & GROWTH FACTOR REVIEWS | 2000年 / 11卷 / 04期
关键词：
Wnt signaling; beta-catenin; TCF/LEF; APC; axin;
D O I：
10.1016/S1359-6101(00)00011-3
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The Wnt/Wingless signaling transduction pathway plays an important role in both embryonic development and tumorigenesis. beta-Catenin, a key component of the Wnt signaling pathway, interacts with the TCF/LEF family of transcription factors and activates transcription of Wnt target genes. Recent studies have revealed that a number of proteins such as, the tumor suppressor APC and Axin are involved in the regulation of the Wnt signaling pathway. Furthermore, mutations in APC or beta-catenin have been found to be responsible for the genesis of human cancers. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：273 / 282
页数：10
相关论文
共 110 条
[1]   Single amino acid substitutions in proteins of the armadillo gene family abolish their binding to alpha-catenin [J].
Aberle, H ;
Schwartz, H ;
Hoschuetzky, H ;
Kemler, R .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (03) :1520-1526
[2]   beta-catenin is a target for the ubiquitin-proteasome pathway [J].
Aberle, H ;
Bauer, A ;
Stappert, J ;
Kispert, A ;
Kemler, R .
EMBO JOURNAL, 1997, 16 (13) :3797-3804
[3]   Regulation of armadillo by a Drosophila APC inhibits neuronal apoptosis during retinal development [J].
Ahmed, Y ;
Hayashi, S ;
Levine, A ;
Wieschaus, E .
CELL, 1998, 93 (07) :1171-1182
[4]   THE TUMOR-SUPPRESSOR GENE-PRODUCT APC BLOCKS CELL-CYCLE PROGRESSION FROM G(0)/G(1) TO S-PHASE [J].
BAEG, GH ;
MATSUMINE, A ;
KURODA, T ;
BHATTACHARJEE, RN ;
MIYASHIRO, I ;
TOYOSHIMA, K ;
AKIYAMA, T .
EMBO JOURNAL, 1995, 14 (22) :5618-5625
[5]   Functional interaction of an axin homolog, conductin, with β-catenin, APC, and GSK3β [J].
Behrens, J ;
Jerchow, BA ;
Würtele, M ;
Grimm, J ;
Asbrand, C ;
Wirtz, R ;
Kühl, M ;
Wedlich, D ;
Birchmeier, W .
SCIENCE, 1998, 280 (5363) :596-599
[6]   Functional interaction of beta-catenin with the transcription factor LEF-1 [J].
Behrens, J ;
vonKries, JP ;
Kuhl, M ;
Bruhn, L ;
Wedlich, D ;
Grosschedl, R ;
Birchmeier, W .
NATURE, 1996, 382 (6592) :638-642
[7]   APC: the plot thickens [J].
Bienz, M .
CURRENT OPINION IN GENETICS & DEVELOPMENT, 1999, 9 (05) :595-603
[8]   A beta-catenin/XTcf-3 complex binds to the siamois promoter to regulate dorsal axis specification in Xenopus [J].
Brannon, M ;
Gomperts, M ;
Sumoy, L ;
Moon, RT ;
Kimelman, D .
GENES & DEVELOPMENT, 1997, 11 (18) :2359-2370
[9]   pangolin encodes a Lef-1 homologue that acts downstream of Armadillo to transduce the Wingless signal in Drosophila [J].
Brunner, E ;
Peter, O ;
Schweizer, L ;
Basler, K .
NATURE, 1997, 385 (6619) :829-833
[10]   Wnt signaling: a common theme in animal development [J].
Cadigan, KM ;
Nusse, R .
GENES & DEVELOPMENT, 1997, 11 (24) :3286-3305
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