Synthesis of Mono and Bis[60]fullerene-Based Dicationic Peptoids

被引：11
|
作者：
Jennepalli, Sreenu [1 ]
Hammer, Katherine A. [2 ]
Riley, Thomas V. [2 ]
Pyne, Stephen G. [1 ]
Keller, Paul A. [1 ]
机构：
[1] Univ Wollongong, Sch Chem, Wollongong, NSW 2522, Australia
[2] Univ Western Australia, Sch Pathol & Lab Med, Crawley, WA 6009, Australia
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2015年 / 2015卷 / 01期
基金：
英国医学研究理事会;
关键词：
Medicinal chemistry; Antibiotics; Amino acids; Peptides; Fullerenes; Template synthesis; AMINO-ACIDS; STAPHYLOCOCCUS-AUREUS; GENE DELIVERY; ANTIBACTERIAL; FULLERENE; VANCOMYCIN; PEPTIDES; ESTERS; DRUGS;
D O I：
10.1002/ejoc.201403046
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Increasing numbers of biological applications of fullerenyl amino acids and their derivatives encouraged us to synthesise [60]fullerenyldihydropyrrole peptides, prepared from the coupling of mono- and bis[60]fullerenyldihydropyrrolecarboxylic acids 4, 5 and 41 with presynthesised peptides 13, 16, 24, 28, 29 and 46. The resulting hydrophobic scaffolded di- and tetra-cationic derivatives were tested against Staphylococcus aureus NCTC 6571 and Escherichia coli NCTC 10418. The synthesis, characterisation and biological results are discussed in this paper.
引用
收藏
页码：195 / 201
页数：7
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