Gastrodin suppresses pyroptosis and exerts neuroprotective effect in traumatic brain injury model by inhibiting NLRP3 inflammasome signaling pathway

被引:30
作者
Yang, Fei [1 ]
Li, Guangzhao [1 ]
Lin, Bin [1 ]
Zhang, Kaipeng [1 ]
机构
[1] First Peoples Hosp Hefei, Dept Neurosurg, Hefei 230061, Anhui, Peoples R China
关键词
Traumatic brain injury (TBI); Gastrodin (GAS); Pyroptosis; NLRP3; ELATA-BLUME; ACTIVATION; STRESS;
D O I
10.31083/j.jin2102072
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Traumatic brain injury (TBI), also known as head injury or brain injury, refers to the head injury caused by mechanical impact. It is necessary to develop effective new therapies for TBI injury. Gastrodin (GAS) is the main bioactive ingredient from the rhizome of Gastrodia elata and has significant therapeutic effect on nervous system diseases. However, the protective effects of GAS on brain tissue and related regulatory mechanism in traumatic brain injury remain elusive. Herein, we explored the role of GAS in traumatic brain injury and its related mechanism. We found Gastrodin reduced brain tissue injury and improved functional recovery of injury nerve in TBI rats, and alleviated inflammation. Gastrodin decreased the level of pyroptosis in brain tissue of TBI rats. Further, we found GAS suppressed NLRP3 inflammasome signaling pathway, and therefore suppressed pyroptosis and exerted neuroprotective effect. GAS could serve as a promising drug for TBI treatment.
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页数:6
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共 25 条
  • [1] The Utility of Serum Procalcitonin in Diagnosing Paroxysmal Sympathetic Hyperactivity in Patients with Traumatic Brain Injury
    Bindra, Ashish
    Chowdhary, Vineet
    Dube, Surya K.
    Goyal, Keshav
    Mathur, Purva
    [J]. INDIAN JOURNAL OF CRITICAL CARE MEDICINE, 2021, 25 (05) : 580 - 583
  • [2] Chen L, 2021, PHYTOMEDICINE, P89
  • [3] Polybenzyls from Gastrodia elata, their agonistic effects on melatonin receptors and structure-activity relationships
    Chen, Si-Yue
    Geng, Chang-An
    Ma, Yun-Bao
    Huang, Xiao-Yan
    Yang, Xiao-Tong
    Su, Li-Hua
    He, Xiao-Feng
    Li, Tian-Ze
    Deng, Zhen-Tao
    Gao, Zhen
    Zhang, Xue-Mei
    Chen, Ji-Jun
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY, 2019, 27 (15) : 3299 - 3306
  • [4] Long-Term Healthcare Expenditures Following Combat-Related Traumatic Brain Injury
    Dalton, Michael K.
    Jarman, Molly P.
    Manful, Adoma
    Koehlmoos, Tracey P.
    Cooper, Zara
    Weissman, Joel S.
    Schoenfeld, Andrew J.
    [J]. MILITARY MEDICINE, 2022, 187 (3-4) : 513 - 517
  • [5] Feng X., 2021, MOL MED REP, V24, P1
  • [6] Hua Zhong-Yi, 2019, Zhongguo Zhong Yao Za Zhi, V44, P1004, DOI 10.19540/j.cnki.cjcmm.2019.0018
  • [7] Gastrodia elata alleviates mutant huntingtin aggregation through mitochondrial function and biogenesis mediation
    Huang, Chuen-Lin
    Wang, Kaw-Chen
    Yang, Ying-Chen
    Chiou, Chun-Tang
    Tan, Chia-Hui
    Lin, Yun-Lian
    Huang, Nai-Kuei
    [J]. PHYTOMEDICINE, 2018, 39 : 75 - 84
  • [8] Morphological control of mitochondria as the novel mechanism of Gastrodia elata in attenuating mutant huntingtin-induced protein aggregations
    Huang, Nai-Kuei
    Lin, Chung-Chih
    Lin, Yun-Lian
    Huang, Chuen-Lin
    Chiou, Chun-Tang
    Lee, Yi-Chao
    Lee, Shu-Yi
    Huang, Hung-Tse
    Yang, Ying-Chen
    [J]. PHYTOMEDICINE, 2019, 59
  • [9] The NLRP3 inflammasome: role in airway inflammation
    Im, H.
    Ammit, A. J.
    [J]. CLINICAL AND EXPERIMENTAL ALLERGY, 2014, 44 (02) : 160 - 172
  • [10] Mouse closed head traumatic brain injury replicates the histological tau pathology pattern of human disease: characterization of a novel model and systematic review of the literature
    Kahriman, Aydan
    Bouley, James
    Smith, Thomas W.
    Bosco, Daryl A.
    Woerman, Amanda L.
    Henninger, Nils
    [J]. ACTA NEUROPATHOLOGICA COMMUNICATIONS, 2021, 9 (01) : 118