Ruthenium(ii)-catalyzed chemoselective deacylative annulation of 1,3-diones with sulfoxonium ylides via C-C bond activation

被引：55

作者：

Wen, Si ^{[1
]}

Lv, Weiwei ^{[1
]}

Ba, Dan ^{[1
]}

Liu, Jing ^{[1
]}

Cheng, Guolin ^{[1
]}

机构：

[1] Huaqiao Univ, Coll Mat Sci & Engn, Xiamen 361021, Fujian, Peoples R China

来源：

CHEMICAL SCIENCE | 2019年 / 10卷 / 39期

关键词：

CARBON-CARBON BOND; REGIOSPECIFIC SYNTHESIS; POLYSUBSTITUTED FURANS; ARYL KETONES; H BONDS; CLEAVAGE; CATALYSIS; INSERTION; PYRROLES; FUNCTIONALIZATION;

D O I：

10.1039/c9sc03245b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The first successful example of deacylative annulation of 1,3-diones with sulfoxonium ylides was achieved through Ru(ii)-catalyzed C-C bond activation. The excellent chemoselectivity and broad substrate scope render this method a practical and versatile approach for the preparation of (hetero)aryl and alkenyl substituted furans, which are valuable units in many biologically active compounds and functional materials. A preliminary mechanistic study reveals that this process involves a deacylative alpha-ruthenation to generate key alkyl Ru(ii) intermediates with the release of a benzoic acid fragment.

引用

页码：9104 / 9108

页数：5

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