Immune cell profiling in the cerebrospinal fluid of patients with primary angiitis of the central nervous system reflects the heterogeneity of the disease

被引：16

作者：

Strunk, Daniel ^{[1
]}

Schulte-Mecklenbeck, Andreas ^{[1
]}

Golombeck, Kristin S. ^{[1
]}

zu Hoerste, Gerd Meyer ^{[1
]}

Melzer, Nico ^{[1
]}

Beuker, Carolin ^{[1
]}

Schmidt, Antje ^{[1
]}

Wiendl, Heinz ^{[1
]}

Meuth, Sven G. ^{[1
]}

Gross, Catharina C. ^{[1
]}

Minnerup, Jens ^{[1
]}

机构：

[1] Univ Munster, Univ Hosp Munster, Clin Neurol, Inst Translat Neurol, D-48149 Munster, Germany

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2018年 / 321卷

关键词：

Cerebrospinal fluid; Flow cytometry; PACNS; CEREBRAL AMYLOID ANGIOPATHY; BETA-RELATED ANGIITIS; GRANULOMATOUS-ANGIITIS; TAKAYASUS-ARTERITIS; NK CELLS; EXPRESSION; TISSUE; BLOOD;

D O I：

10.1016/j.jneuroim.2018.06.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Primary angiitis of the central nervous system (PACNS) is a rare and heterogeneous inflammatory disease of the CNS vasculature with poorly understood pathophysiology. Comprehensive immune-cell phenotyping revealed increased frequencies of leukocytes in the cerebrospinal fluid (CSF) of PACNS patients compared to patients with multiple sclerosis, ischemic stroke, and somatoform disorders (n = 18 per group). Changes in the intrathecal immune-cell profile were heterogeneous in PACNS. While proportions of T-cell subsets remained unaltered, some PACNS patients showed a shift toward NK- or B cells. Intrathecal immunoglobulin synthesis was observed in a subgroup of PACNS patients with an increased frequency of antibody producing plasma cells.

引用

页码：109 / 116

页数：8

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