Preparation of irbesartan composite microparticles by supercritical aerosol solvent extraction system for dissolution enhancement

被引：21
|
作者：
Yan, Tingyuan [1 ]
Zhang, Yi [3 ]
Ji, Mengru [1 ]
Wang, Zhixiang [3 ]
Yan, Tingxuan [1 ,2 ]
机构：
[1] Anhui Univ Technol, Sch Chem & Chem Engn, Maanshan 243002, Anhui, Peoples R China
[2] Anhui Univ Technol, Biochem Engn Res Ctr, Maanshan 243002, Anhui, Peoples R China
[3] China Pharmaceut Univ, Sch Engn, Nanjing 210009, Jiangsu, Peoples R China
来源：
JOURNAL OF SUPERCRITICAL FLUIDS | 2019年 / 153卷
关键词：
Irbesartan; Supercritical aerosol solvent extraction system; Solubility; Dissolution enhancement; Solid dispersion; BIOAVAILABILITY ENHANCEMENT; ANTISOLVENT PRECIPITATION; RAPID EXPANSION; NANOPARTICLES; PRESSURE; INDOMETHACIN; NANONIZATION; TEMPERATURE; SOLUBILITY; PARTICLES;
D O I：
10.1016/j.supflu.2019.104594
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
In this study, irbesartan (IST) microparticles, an IST ihydroxypropyl-beta-cyclodextrin (HP-beta-CD) inclusion complex, and an IST/polyvinylpyrrolidone (PVP) complex were prepared using a supercritical aerosol solvent extraction system (ASES). The goal was to improve the solubility and dissolution rate of IST, which is an angiotensin II receptor blocker and exhibits solubility-limited oral bioavailability in pharmacokinetics. It is noteworthy that these three drug delivery systems show a higher solubility and dissolution rate of IST compared with raw IST. Fourier-transform infrared spectroscopy, differential scanning calorimetry, X-ray diffraction, and scanning electron microscopy analyses were conducted to study the physicochemical properties of IST before and after ASES processing, and to confirm the formation of the IST complexes with HP-beta-CD and PVP. This study provides valuable information for the potential clinical application of IST microparticles and IST composite particles synthesized using the ASES process. (C) 2019 Elsevier B.V. All rights rights reserved.
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页数：8
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