Hepatic Stellate Cells and Fibrogenesis in Hepatitis C Virus Infection: An Ultrastructural Insight

被引：9

作者：

Mansy, Soheir S. ^{[1
]}

ElKhafif, Nagwa A. ^{[2
]}

AbelFatah, Ahmed S. ^{[3
]}

Yehia, Hoda A. ^{[1
]}

Mostafa, Ibrahim ^{[3
]}

机构：

[1] Theodor Bilharz Res Inst, Electron Microscopy Res Dept Pathol, Imbaba, Guiza, Egypt

[2] Theodor Bilharz Res Inst, Electron Microscopy Res Dept Haematol, Imbaba, Guiza, Egypt

[3] Theodor Bilharz Res Inst, Dept Gastroenterol & Hepatol, Imbaba, Guiza, Egypt

来源：

ULTRASTRUCTURAL PATHOLOGY | 2010年 / 34卷 / 02期

关键词：

electron microscopy; fibrogenesis; hepatic fibrosis; hepatic stellate cells (HSCs); hepatitis C virus; myofibroblast-like; LIVER FIBROSIS; TISSUE-REPAIR; APOPTOSIS; MYOFIBROBLAST; MARKER; INJURY;

D O I：

10.3109/01913120903506645

中图分类号：

TH742 [显微镜];

学科分类号：

摘要：

An ultrastructural quantitative assessment of hepatic stellate cells (HSCs) was made in relation to hepatic fibrosis, apoptotic cellular changes, intracellular fat deposition, circulating inflammatory cells in the sinusoids, and the necroinflammatory activity in liver specimens of 33 patients proven to be positive for hepatitis C virus (HCV)-RNA by polymerase chain reaction with the intention that electron microscopy may throw more light on the role of HSCs in the complicated process of fibrogenesis. A detailed review concerning these parameters and observed evidence suggesting the potential properties of HSCs to recycle cellular debris into collagen fibers are reported.</.

引用

页码：62 / 67

页数：6

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