Plant lectins: Potential antineoplastic drugs from bench to clinic

被引：172
作者：
Liu, Bo [1 ]
Bian, He-jiao [1 ]
Bao, Jin-ku [1 ]
机构：
[1] Sichuan Univ, Sch Life Sci, Chengdu 610064, Peoples R China
来源：
CANCER LETTERS | 2010年 / 287卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Plant lectin; Cancer; Apoptosis; Autophagy; Drug; RECOMBINANT MISTLETOE LECTIN; VISCUM-ALBUM-COLORATUM; MANNOSE-BINDING LECTIN; CONCANAVALIN-A; POLYGONATUM-CYRTONEMA; MOLECULAR-MECHANISMS; INDUCED APOPTOSIS; OPHIOPOGON-JAPONICUS; CELL-PROLIFERATION; CANCER-CELLS;
D O I：
10.1016/j.canlet.2009.05.013
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Plant lectins, carbohydrate-binding proteins distributed widely in a variety of plant species, have drawn a rising attention for cancer biologists due to their remarkable anti-tumour properties. In this review, we present a brief outline of the up-to-date advances of plant lectins in elucidating their complex anti-cancer mechanisms implicated in apoptosis and autophagy. In addition, we further discuss the pre-clinical and clinical studies of plant lectins for their potential therapeutic applications. In conclusion, these inspiring findings would open a new perspective for plant lectins as potential antineoplastic drugs from bench to clinic. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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页码：1 / 12
页数：12
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