Persistent replication of SARS-CoV-2 in a severely immunocompromised patient treated with several courses of remdesivir

被引：40

作者：

Camprubi, Daniel ^{[1
]}

Gaya, Anna ^{[2
]}

Marcos, Maria Angeles ^{[3
]}

Marti-Soler, Helena ^{[1
]}

Soriano, Alex ^{[4
]}

Mosquera, Maria del Mar ^{[3
]}

Oliver, Aina ^{[2
]}

Santos, Marta ^{[3
]}

Munoz, Jose ^{[1
]}

Garcia-Vidal, Carol ^{[4
]}

机构：

[1] Univ Barcelona, Barcelona Inst Global Hlth ISGlobal Hosp Clin, C Rosello 132, Barcelona 08036, Spain

[2] Hosp Clinic, Hematol Dept, Barcelona, Spain

[3] Hosp Clinic, Microbiol Dept, Barcelona, Spain

[4] Hosp Clinic, Infect Dis Dept, Barcelona, Spain

来源：

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES | 2021年 / 104卷

关键词：

Remdesivir; COVID-19; SARS-CoV-2; Immunosuppression; Lymphoma;

D O I：

10.1016/j.ijid.2020.12.050

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Microbiological response of SARS-CoV-2 to remdesivir in immunocompromised patients has not been evaluated. We present the case of a severely immunocompromised patient with persistent replication of SARS-CoV-2, who required different courses of remdesivir. Short courses of remdesivir might be insufficient in immunocompromised patients due to prolonged viral clearance. ? 2020 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-ncnd/4.0/). Microbiological response of SARS-CoV-2 to remdesivir in immunocompromised patients has not been evaluated. We present the case of a severely immunocompromised patient with persistent replication of SARS-CoV-2, who required different courses of remdesivir. Short courses of remdesivir might be insufficient in immunocompromised patients due to prolonged viral clearance. ? 2020 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc

引用

页码：379 / 381

页数：3

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