STATINS AND THE RISK FOR CORONARY IN-STENT RESTENOSIS IN DIABETIC PATIENTS

被引：6

作者：

Nita, Daniel ^{[1
]}

Ionescu, Mihaela ^{[2
]}

Mazilu, Laura ^{[2
]}

Suceveanu, Andra Iulia ^{[2
]}

Munteanu, Alice ^{[1
]}

Ionescu, Paris ^{[2
]}

Tuta, Liliana Ana ^{[2
]}

Buicu, Florin ^{[3
]}

Parepa, Irinel Raluca ^{[2
]}

机构：

[1] Armys Ctr Cardiovasc Dis, Bucharest, Romania

[2] Ovidius Univ Constanta, Fac Gen Med, Constanta, Romania

[3] George Emil Palade Univ Med Pharm Sci & Technol, Targu Mures, Romania

来源：

FARMACIA | 2021年 / 69卷 / 03期

关键词：

statins; coronary in-stent restenosis; diabetes mellitus; RANDOMIZED-TRIAL; VESSEL SIZE; INTERVENTION; ATORVASTATIN; PREDICTORS; PREVENTION; REVASCULARIZATION; IMPLANTATION; THROMBOSIS; DISEASE;

D O I：

10.31925/farmacia.2021.3.21

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Diabetes mellitus is considered to be an independent risk factor for the progression of coronary artery disease, due to the associated pro-atherosclerotic status, and also an important predictor of poor outcomes after both coronary artery bypass grafting and percutaneous coronary intervention. Even in the contemporary era of newer-generation stents and despite remarkable technological advances, in-stent restenosis is still a major problem. The aim of our study was to identify risk factors for restenosis in the first year after stent deployment in 95 diabetic patients with coronary heart disease. Our results suggest that a larger stent diameter and the use of statins positively influence the risk of in-stent restenosis in the first year after stent implantation. Systemic statin therapy should be considered in all interventional treated diabetic patients, in order to reduce the risk of in-stent restenosis, particularly in high-risk patients.

引用

收藏

页码：576 / 584

页数：9

相关论文

共 41 条

[1] Fluvastatin reduces the impact of diabetes on long-term outcome after coronary intervention - A Lescol Intervention Prevention Study (LIPS) substudy [J].

Arampatzis, CA ;

Goedhart, D ;

Serruys, PW ;

Saia, F ;

Lemos, PA ;

de Feyter, P .

AMERICAN HEART JOURNAL, 2005, 149 (02) :329-335

[2]

Armstrong Ehrin J, 2014, J Diabetes Sci Technol, V8, P581, DOI 10.1177/1932296813517058

[3] Revascularization for coronary artery disease in diabetes mellitus: Angioplasty, stents and coronary artery bypass grafting [J].

Aronson, Doron ;

Edelman, Elazer R. .

REVIEWS IN ENDOCRINE & METABOLIC DISORDERS, 2010, 11 (01) :75-86

[4] Impact of statin therapy intensity on endothelial progenitor cells after percutaneous coronary intervention in diabetic patients. The REMEDY-EPC late study [J].

Briguori, Carlo ;

Quintavalle, Cristina ;

D'Alessio, Francesca ;

Donahue, Michael ;

Roscigno, Giuseppina ;

De Micco, Francesca ;

Focaccio, Amelia ;

Visconti, Gabriella ;

del Vecchio, Luigi ;

Madonna, Rosalinda ;

De Caterina, Raffaele ;

Condorelli, Gerolama .

INTERNATIONAL JOURNAL OF CARDIOLOGY, 2017, 244 :112-118

[5] Stent thrombosis and restenosis: what have we learned and where are we going? The Andreas Gruntzig Lecture ESC 2014 [J].

Byrne, Robert A. ;

Joner, Michael ;

Kastrati, Adnan .

EUROPEAN HEART JOURNAL, 2015, 36 (47) :3320-+

[6]

Cariou B, 2000, DIABETES NUTR METAB, V13, P134

[7] Pathogenesis and pathophysiology of accelerated atherosclerosis in the diabetic heart [J].

D'Souza, Alicia ;

Hussain, Munir ;

Howarth, Frank C. ;

Woods, Niall M. ;

Bidasee, Keshore ;

Singh, Jaipaul .

MOLECULAR AND CELLULAR BIOCHEMISTRY, 2009, 331 (1-2) :89-116

[8] In-Stent Restenosis in the Drug-Eluting Stent Era [J].

Dangas, George D. ;

Claessen, Bimmer E. ;

Caixeta, Adriano ;

Sanidas, Elias A. ;

Mintz, Gary S. ;

Mehran, Roxana .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2010, 56 (23) :1897-1907

[9] Colchicine Treatment for the Prevention of Bare-Metal Stent Restenosis in Diabetic Patients [J].

Deftereos, Spyridon ;

Giannopoulos, Georgios ;

Raisakis, Konstantinos ;

Kossyvakis, Charalambos ;

Kaoukis, Andreas ;

Panagopoulou, Vasiliki ;

Driva, Metaxia ;

Hahalis, George ;

Pyrgakis, Vlasios ;

Alexopoulos, Dimitrios ;

Manolis, Antonis S. ;

Stefanadis, Christodoulos ;

Cleman, Michael W. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2013, 61 (16) :1679-1685

[10] Vessel size and outcome after coronary drug-eluting stent placement:: Results from a large cohort of patients treated with sirolimus- or paclitaxel-eluting stents [J].

Elezi, Shpend ;

Dibra, Alban ;

Mehilli, Julinda ;

Pache, Juergen ;

Wessely, Rainer ;

Schoemig, Albert ;

Kastrati, Adnan .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2006, 48 (07) :1304-1309

← 1 2 3 4 5 →