Antiperoxide effect of S-allyl cysteine sulfoxide, an insulin secretagogue, in diabetic rats

被引：157
作者：
Augusti, KT [1 ]
Sheela, CG [1 ]
机构：
[1] UNIV KERALA,DEPT BIOCHEM,THIRUVANANTHAPURAM 695581,INDIA
来源：
EXPERIENTIA | 1996年 / 52卷 / 02期
关键词：
antioxidant; S-allyl cysteine sulfoxide; insulin secretagogue; albino rats; glibenclamide; malondialdehyde; hydroperoxide; superoxide dismutase;
D O I：
10.1007/BF01923354
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Treatment of alloxan diabetic rats with the antioxidant S-allyl cysteine sulfoxide (SACS) isolated from garlic (Allium sativum Linn), ameliorated the diabetic condition almost to the same extent as did glibenclamide and insulin. In addition, SACS controlled lipid peroxidation better than the other two drugs. Furthermore, SACS significantly stimulated in vitro insulin secretion from B cells isolated from normal rats. Hence it can be surmised that the beneficial effects of SACS could be due to both its antioxidant and its secretagogue actions. The former effect is more predominant and the latter is only secondary. These effects highlight the therapeutic value of garlic, which is a component of many diets.
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页码：115 / 119
页数：5
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