Characteristics and impact of cardiovascular comorbidities on coronavirus disease 2019 in women: A multicentre cohort study

被引：4

作者：

Weizman, Orianne ^{[1
,2
]}

Mika, Delphine ^{[3
]}

Cellier, Joffrey ^{[4
]}

Geneste, Laura ^{[5
]}

Trimaille, Antonin ^{[6
]}

Pommier, Thibaut ^{[7
]}

Panagides, Vassili ^{[8
]}

Marsou, Wassima ^{[9
]}

Deney, Antoine ^{[10
]}

Attou, Sabir ^{[11
]}

Delmotte, Thomas ^{[12
]}

Ribeyrolles, Sophie ^{[13
]}

Chemaly, Pascale ^{[14
]}

Karsenty, Clement ^{[10
]}

Giordano, Gauthier ^{[1
]}

Gautier, Alexandre ^{[14
]}

Chaumont, Corentin ^{[15
]}

Guilleminot, Pierre ^{[7
]}

Sagnard, Audrey ^{[7
]}

Pastier, Julie ^{[7
]}

Duceau, Baptiste ^{[2
]}

Sutter, Willy ^{[2
]}

Fauvel, Charles ^{[15
]}

Pezel, Theo ^{[16
]}

Bonnet, Guillaume ^{[2
,15
,17
]}

Cohen, Ariel ^{[18
]}

Waldmann, Victor ^{[2
,4
]}

机构：

[1] Ctr Hosp Reg Univ Nancy, F-54511 Vandoeuvre Les Nancy, France

[2] Univ Paris, PARCC, INSERM, F-75015 Paris, France

[3] Univ Paris Saclay, INSERM, UMR S 1180, F-92296 Chatenay Malabry, France

[4] Univ Paris, Hop Europeen Georges Pompidou, AP HP, F-75015 Paris, France

[5] Ctr Hosp Univ Amiens Picardie, F-80000 Amiens, France

[6] Ctr Hosp Reg Univ Strasbourg, Nouvel Hop Civil, F-67000 Strasbourg, France

[7] Ctr Hosp Univ Dijon, F-21000 Dijon, France

[8] Ctr Hosp Univ Marseille, F-13005 Marseille, France

[9] Univ Catholique Lille, Fac Med & Maieut, GCS Grp Hop Inst Catholique Lille, Lille, France

[10] Ctr Hosp Univ Toulouse, F-31400 Toulouse, France

[11] Ctr Hosp Univ Caen Normandie, F-14000 Caen, France

[12] Ctr Hosp Univ Reims, F-51100 Reims, France

[13] Inst Mutualiste Montsouris, F-75014 Paris, France

[14] Inst Cardiovasc Paris Sud, F-91300 Massy, France

[15] Rouen Univ Hosp, FHU REMOD VHF, F-76000 Rouen, France

[16] Univ Paris, Hop Lariboisiere, AP HP, F-75010 Paris, France

[17] Univ Bordeaux, Ctr Hosp Univ Bordeaux, Hop Cardiol Haut Leveque, Pessac, France

[18] Hosp St Antoine, AP HP, F-75012 Paris, France

来源：

ARCHIVES OF CARDIOVASCULAR DISEASES | 2021年 / 114卷 / 05期

关键词：

COVID-19; SARS-CoV-2; Women; Outcomes; Risk factors; CLINICAL CHARACTERISTICS; COVID-19; EPIDEMIOLOGY; OUTCOMES; GUIDELINES; STATEMENT; DIAGNOSIS;

D O I：

10.1016/j.acvd.2021.04.002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background. & mdash; Although women account for up to half of patients hospitalized for coronavirus disease 2019 (COVID-19), no specific data have been reported in this population. Aims. & mdash; To assess the burden and impact of cardiovascular comorbidities in women with COVID19. Methods. & mdash; All consecutive patients hospitalized for COVID-19 across 24 hospitals from 26 February to 20 April 2020 were included. The primary composite outcome was transfer to an intensive care unit or in-hospital death. Results. & mdash; Among 2878 patients, 1212 (42.1%) were women. Women were older (68.3 +/- 18.0 vs. 65.4 +/- 16.0 years; P < 0.001), but had less prevalent cardiovascular comorbidities than men. Among women, 276 (22.8%) experienced the primary outcome, including 161 (13.3%) transfers to an intensive care unit and 115 (9.5%) deaths without transfer to intensive care unit. The rate of in-hospital death or transfer to an intensive care unit was lower in women versus men (crude hazard ratio [HR]: 0.62, 95% confidence interval [CI]: 0.53 & mdash;0.72). Age (adjusted HR: 1.05 per 5-year increase, 95% CI: 1.01 & mdash;1.10), body mass index (adjusted HR: 1.06 per 2-unit increase, 95% CI: 1.02 & mdash;1.10), chronic kidney disease (adjusted HR: 1.57, 95% CI: 1.11 & mdash;2.22) and heart failure (adjusted HR: 1.52, 95% CI: 1.04 & mdash;2.22) were independently associated with the primary outcome in women. Elevated B-type natriuretic peptide/N-terminal prohormone of B-type natriuretic peptide (adjusted HR: 2.41, 95% CI: 1.70 & mdash;3.44) and troponin (adjusted HR: 2.00, 95% CI: 1.39 & mdash;2.88) concentrations at admission were also associated with the primary outcome, even in women free of previous coronary artery disease or heart failure. Conclusions. & mdash; Although female sex was associated with a lower risk of transfer to an intensive care unit or in-hospital death, COVID-19 remained associated with considerable morbimortality in women, especially in those with cardiovascular diseases. (c) 2021 Published by Elsevier Masson SAS.

引用

页码：394 / 406

页数：13

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