Superparamagnetic pH-Sensitive Multi layer Hybrid Hollow Microspheres for Targeted Controlled Release

被引：69
作者：
Mu, Bin
Liu, Peng [1 ]
Dong, Yun
Lu, Chunyin
Wu, Xueli
机构：
[1] Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China
来源：
JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY | 2010年 / 48卷 / 14期
关键词：
hybrid hollow microspheres; layer-by-layer assembly; pH sensitive; superparamagnetic; targeted controlled release; IRON-OXIDE NANOPARTICLES; POLYELECTROLYTE CAPSULES; BIOMEDICAL APPLICATIONS; POLYMER MICROCAPSULES; DRUG-DELIVERY; SURFACE; PARTICLES; SPHERES; NANOCARRIERS; MULTILAYERS;
D O I：
10.1002/pola.24095
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
The superparamagnetic multilayer hybrid hollow microspheres have been fabricated using the layer-by-layer assembly technique by the electrostatic interaction between the polyelectrolyte cation chitosan (CS) and the hybrid anion citrate modified ferroferric oxide nanoparticles (Fe3O4-CA) onto the sacrificial polystyrene sulfonate microspheres templates after etching the templates by dialysis. The saturation magnetization and magnetite contents of the superparamagnetic multilayer hybrid hollow microspheres were 32.46 emu/g and 51.3%, respectively. The hybrid hollow microspheres showed pH-sensitive characteristics. The adsorption and release of the basic dye (methylene blue) were applied to investigate the interaction between the amino groups of CS and the carboxyl groups of the Fe3O4-CA nanoparticles in different pH media. The superparamagnetic pH-sensitive multilayer hybrid hollow microspheres are expected to be used for the targeted controlled release of drugs or in diagnostics. (C) 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 48: 3135 3144, 2010
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页码：3135 / 3144
页数：10
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