Expression of lysophosphatidic acid receptors and vascular endothelial growth factor mediating lysophosphatidic acid in the development of human ovarian cancer

被引：76

作者：

Fujita, T

Miyamoto, S ^{[1
]}

Onoyama, I

Sonoda, K

Mekada, E

Nakano, H

机构：

[1] Kyushu Univ, Grad Sch Med Sci, Dept Obstet & Gynecol, Higashi Ku, Fukuoka 8128582, Japan

[2] Osaka Univ, Res Inst Microbial Dis, Dept Cell Biol, Suita, Osaka 5650871, Japan

来源：

CANCER LETTERS | 2003年 / 192卷 / 02期

关键词：

lysophosphatidic acid receptors; vascular endothelial growth factor; interleukin-8; reverse transcription polymerase chain reaction;

D O I：

10.1016/S0304-3835(02)00713-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Lysophosphatidic acid (LPA) receptors including LPA(1), LPA(2), and LPA(3) mediate lysophosphatidic acid signals. We analyzed the expression of LPA receptors, vascular endothelial growth factor (VEGF), and interleukin-8 in 97 patients from normal ovary to ovarian cancer, using reverse transcription polymerase chain reaction. LPA2, LPA3, and VEGF expression ratios significantly increased in cancer, compared to those in non-cancerous state (P < 0.05). A significant correlation in the kxpression ratios between LPA(2) or LPA(3) and VEGF was found (gamma = 0.617, P < 0.0001; gamma = 0.431, P < 0.001) in patients with cancer. These results suggested that LPA2 and LPA3 may be involved in VEGF expression mediated by LPA signals in human ovarian oncogenesis. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：161 / 169

页数：9

共 45 条

[1] A rat G protein-coupled receptor selectively expressed in myelin-forming cells [J].