Bisphenol-A: a new diabetogenic factor?

被引：80
作者：
Alonso-Magdalena, Paloma [1 ,2 ]
Belin Ropero, Ana [1 ,2 ]
Soriano, Sergi [1 ,2 ]
Quesada, Ivan [1 ,2 ]
Nadal, Angel [1 ,2 ]
机构：
[1] Univ Miguel Hernandez Elche, Inst Bioengn, Elche, Spain
[2] CIBERDEM, CIBER Diabet & Associated Metab Dis, Elche, Spain
来源：
HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM | 2010年 / 9卷 / 02期
关键词：
Bisphenol-A; Diabetes; Estradiol; Estrogen Receptors; Glucose Homeostasis; Islet of Langerhans; ESTROGEN-RECEPTOR-ALPHA; ADIPOSE-TISSUE; INSULIN-RESISTANCE; GLUCOSE-HOMEOSTASIS; INTACT ISLETS; METABOLIC SYNDROME; ENERGY-BALANCE; HUMAN EXPOSURE; CELL-FUNCTION; BODY-WEIGHT;
D O I：
10.1007/BF03401277
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The aim of this review was to analyze the potential effects of environmental chemicals on homeo-static control related to glycemia and energy balance. Many of the environmental chemicals can mimic or interfere with the action of hormones and are generally referred to as "endocrine disruptors". Among these compounds, polychlorinated biphenyls, dioxins, phthalates and bisphenol-A have been correlated with alterations in blood glucose homeostasis in humans. In rodents it has been demonstrated that small doses of bisphenol-A have profound effects on glucose metabolism. Therefore, this altered blood glucose homeostasis may enhance the development of type 2 diabetes.
引用
收藏
页码：118 / 126
页数：9
相关论文
共 85 条
  • [1] Promoting insulin secretion in pancreatic, islets by means of bisphenol A and nonylphenol via intracellular estrogen receptors
    Adachi, T
    Yasuda, K
    Mori, C
    Yoshinaga, M
    Aoki, N
    Tsujimoto, G
    Tsuda, K
    [J]. FOOD AND CHEMICAL TOXICOLOGY, 2005, 43 (05) : 713 - 719
  • [2] Screening and testing for endocrine disruption in fish - Biomarkers as "signposts," not "traffic lights," in risk assessment
    Hutchinson, Thomas H.
    Ankley, Gerald T.
    Segner, Helmut
    Tyler, Charles R.
    [J]. ENVIRONMENTAL HEALTH PERSPECTIVES, 2006, 114 : 106 - 114
  • [3] Low doses of bisphenol A and diethylstilbestrol impair Ca2+ signals in pancreatic α-cells through a nonclassical membrane estrogen receptor within intact islets of Langerhans
    Alonso-Magdalena, P
    Laribi, O
    Ropero, AB
    Fuentes, E
    Ripoll, C
    Soria, B
    Nadal, A
    [J]. ENVIRONMENTAL HEALTH PERSPECTIVES, 2005, 113 (08) : 969 - 977
  • [4] Pancreatic Insulin Content Regulation by the Estrogen Receptor ERα
    Alonso-Magdalena, Paloma
    Ropero, Ana B.
    Carrera, M. Pilar
    Cederroth, Christopher R.
    Baquie, Mathurin
    Gauthier, Benoit R.
    Nef, Serge
    Stefani, Enrico
    Nadal, Angel
    [J]. PLOS ONE, 2008, 3 (04):
  • [5] Estrogen receptors:: new players in diabetes mellitus
    Barros, Rodrigo P. A.
    Machado, Ubiratan Fabres
    Gustafsson, Jan-Ake
    [J]. TRENDS IN MOLECULAR MEDICINE, 2006, 12 (09) : 425 - 431
  • [6] Muscle GLUT4 regulation by estrogen receptors ERβ and ERα
    Barros, RPA
    Machado, UF
    Warner, M
    Gustafsson, JÅ
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (05) : 1605 - 1608
  • [7] Suppression of Ca2+ oscillations in glucagon-producing alpha(2)-cells by insulin glucose and amino acids
    Berts, A
    Ball, A
    Gylfe, E
    Hellman, B
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 1996, 1310 (02): : 212 - 216
  • [8] From mice to men: Insights into the insulin resistance syndromes
    Biddinger, SB
    Kahn, CR
    [J]. ANNUAL REVIEW OF PHYSIOLOGY, 2006, 68 : 123 - 158
  • [9] Bisphenol A induces reactive oxygen species generation in the liver of male rats
    Bindhumol, V
    Chitra, KC
    Mathur, PP
    [J]. TOXICOLOGY, 2003, 188 (2-3) : 117 - 124
  • [10] Evidence that oestrogen receptor-α plays an important role in the regulation of glucose homeostasis in mice:: insulin sensitivity in the liver
    Bryzgalova, G
    Gao, H
    Ahren, B
    Zierath, JR
    Galuska, D
    Steiler, TL
    Dahlman-Wright, K
    Nilsson, S
    Gustafsson, JÅ
    Efendic, S
    Khan, A
    [J]. DIABETOLOGIA, 2006, 49 (03) : 588 - 597
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