Recovery from critical illness-induced organ failure: the role of autophagy

被引：43
作者：
Gunst, Jan [1 ,2 ]
机构：
[1] KU Leuven Univ & Hosp, Dept Cellular & Mol Med, Clin Div, Herestr 49, B-3000 Leuven, Belgium
[2] KU Leuven Univ & Hosp, Dept Cellular & Mol Med, Lab Intens Care Med, Herestr 49, B-3000 Leuven, Belgium
来源：
CRITICAL CARE | 2017年 / 21卷
关键词：
Critical illness; Sepsis; Autophagy; Nutrition; Insulin; Multiple organ dysfunction syndrome; PARENTERAL-NUTRITION; ISCHEMIA;
D O I：
10.1186/s13054-017-1786-y
中图分类号：
R4 [临床医学];
学科分类号：
1002 ; 100602 ;
摘要：
Autophagy is a catabolic process by which cells can dispose of damaged content and intracellular microorganisms. Recent evidence implicates autophagy as a crucial repair process necessary to recover from critical illness-induced organ failure. Withholding parenteral nutrition in the acute phase of critical illness activates autophagy and enhances recovery. Several registered drugs have autophagy-stimulating properties, but all lack specificity and none has been investigated in critically ill patients for this purpose.
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页数：3
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