Poorly Differentiated Neuroendocrine Tumor With 18F-Fluciclovine Uptake in a Patient With Metastatic Castrate-Resistant Prostate Cancer

被引：2
作者：
Abiodun-Ojo, Olayinka A. [1 ]
Akintayo, Akinyemi A. [1 ]
Harik, Lara R. [2 ]
Bilen, Mehmet [3 ]
Halkar, Raghuveer K. [1 ]
机构：
[1] Emory Univ, Sch Med, Dept Radiol & Imaging Sci, Atlanta, GA USA
[2] Emory Univ, Sch Med, Dept Pathol & Lab Med, Atlanta, GA 30322 USA
[3] Emory Univ, Winship Canc Inst, Dept Hematol & Med Oncol, Atlanta, GA 30322 USA
来源：
CLINICAL NUCLEAR MEDICINE | 2021年 / 46卷 / 05期
关键词：
F-18-fluciclovine; axumin; F-18-FDG; neuroendocrine tumor; prostate cancer; PET; FDG-PET; UTILITY;
D O I：
10.1097/RLU.0000000000003408
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
F-18-Fluciclovine is an amino acid-based radiopharmaceutical used primarily for PET imaging of patients with biochemical recurrence of prostate cancer. We report a case of a 66-year-old man with recently diagnosed metastatic castrate-resistant prostate cancer and a left supraclavicular lymph node with incidental radiotracer uptake on F-18-fluciclovine PET/CT. Left neck core needle biopsy confirmed high-grade, poorly differentiated carcinoma with neuroendocrine features positive for synaptophysin and chromogranin, and negative for prostate markers.
引用
收藏
页码：E282 / E285
页数：4
相关论文
共 16 条
[1]   Multisite Experience of the Safety, Detection Rate and Diagnostic Performance of Fluciclovine (18F) Positron Emission Tomography/Computerized Tomography Imaging in the Staging of Biochemically Recurrent Prostate Cancer [J].
Bach-Gansmo, Tore ;
Nanni, Cristina ;
Nieh, Peter T. ;
Zanoni, Lucia ;
Bogsrud, Tronde Velde ;
Sletten, Heidi ;
Korsan, Katrine Andersen ;
Kieboom, J. ;
Tade, Funmilayo I. ;
Odewole, Oluwaseun ;
Chau, Albert ;
Ward, Penelope ;
Goodman, Mark M. ;
Fanti, Stefano ;
Schuster, David M. ;
Willoch, Frode .
JOURNAL OF UROLOGY, 2017, 197 (03) :676-682
[2]   Incidental Accumulation of Fluciclovine in Neuroendocrine Tumour in a Patient with Oncological Duplicity [J].
Balazova, Zuzana ;
Cerny, Igor ;
Vyskovsky, Petr .
CASE REPORTS IN ONCOLOGY, 2020, 13 (01) :431-435
[3]   Overexpression of L-Type Amino Acid Transporter 1 (LAT1) and 2 (LAT2): Novel Markers of Neuroendocrine Tumors [J].
Barollo, Susi ;
Bertazza, Loris ;
Watutantrige-Fernando, Sara ;
Censi, Simona ;
Cavedon, Elisabetta ;
Galuppini, Francesca ;
Pennelli, Gianmaria ;
Fassina, Ambrogio ;
Citton, Marilisa ;
Rubin, Beatrice ;
Pezzani, Raffaele ;
Benna, Clara ;
Opocher, Giuseppe ;
Iacobone, Maurizio ;
Mian, Caterina .
PLOS ONE, 2016, 11 (05)
[4]   18F-Fluorodeoxyglucose Positron Emission Tomography Predicts Survival of Patients with Neuroendocrine Tumors [J].
Binderup, Tina ;
Knigge, Ulrich ;
Loft, Annika ;
Federspiel, Birgitte ;
Kjaer, Andreas .
CLINICAL CANCER RESEARCH, 2010, 16 (03) :978-985
[5]   Distinct Imaging Characteristics of Different Metastases From Primary Prostate Adenocarcinoma and Rectal Carcinoid Tumor on 18F-Fluciclovine and 68Ga-DOTATATE PET/CT [J].
Bosserman, Andrew John ;
Dai, Dong ;
Lu, Yang .
CLINICAL NUCLEAR MEDICINE, 2019, 44 (01) :83-84
[6]   PET/CT With 68Ga-DOTA-TATE for Diagnosis of Neuroendocrine Differentiation in Patients With Castrate-Resistant Prostate Cancer [J].
Gofrit, Ofer Nathan ;
Frank, Stephen ;
Meirovitz, Amichay ;
Nechushtan, Hovav ;
Orevi, Marina .
CLINICAL NUCLEAR MEDICINE, 2017, 42 (01) :1-6
[7]   Prostate cancer and neuroendocrine differentiation: more neuronal, less endocrine? [J].
Grigore, Alexandru Dan ;
Ben-Jacob, Eshel ;
Farach-Carson, Mary C. .
FRONTIERS IN ONCOLOGY, 2015, 5
[8]   Neuroendocrine differentiation in hormone refractory prostate cancer following androgen deprivation therapy [J].
Hirano, D ;
Okada, Y ;
Minei, S ;
Takimoto, Y ;
Nemoto, N .
EUROPEAN UROLOGY, 2004, 45 (05) :586-592
[9]   FDG PET-CT demonstration of metastatic neuroendocrine tumor of prostate [J].
Liu, Yiyan .
WORLD JOURNAL OF SURGICAL ONCOLOGY, 2008, 6 (1)
[10]   [18F]Fluciclovine PET/CT: joint EANM and SNMMI procedure guideline for prostate cancer imaging-version 1.0 [J].
Nanni, Cristina ;
Zanoni, Lucia ;
Bach-Gansmo, Tore ;
Minn, Heikki ;
Willoch, Frode ;
Bogsrud, Trond Velde ;
Edward, Ephraim Parent ;
Savir-Baruch, Bital ;
Teoh, Eugene ;
Ingram, Fenton ;
Fanti, Stefano ;
Schuster, David M. .
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2020, 47 (03) :579-591
12