Metformin as a Tool to Target Aging

被引：771

作者：

Barzilai, Nir ^{[1
]}

Crandall, Jill P. ^{[1
]}

Kritchevsky, Stephen B. ^{[2
,3
]}

Espeland, Mark A. ^{[2
,3
]}

机构：

[1] Albert Einstein Coll Med, Inst Aging Res, Bronx, NY 10461 USA

[2] Wake Forest Sch Med, Wake Forest Older Amer Independence Ctr, Winston Salem, NC 27157 USA

[3] Wake Forest Sch Med, Sticht Ctr Aging, Winston Salem, NC 27157 USA

来源：

CELL METABOLISM | 2016年 / 23卷 / 06期

关键词：

EXTENDS LIFE-SPAN; DIABETES PREVENTION PROGRAM; MILD COGNITIVE IMPAIRMENT; PANCREATIC-CANCER; NORDIHYDROGUAIARETIC ACID; OLDER-ADULTS; C; ELEGANS; IGF-I; TYPE-2; INTERVENTIONS;

D O I：

10.1016/j.cmet.2016.05.011

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Aging has been targeted by genetic and dietary manipulation and by drugs in order to increase lifespan and health span in numerous models. Metformin, which has demonstrated protective effects against several age-related diseases in humans, will be tested in the TAME (Targeting Aging with Metformin) trial, as the initial step in the development of increasingly effective next-generation drugs.

引用

页码：1060 / 1065

页数：6

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