Making HSCs in vitro: don't forget the hemogenic endothelium

被引：19
作者：
Blaser, Bradley W. [1 ]
Zon, Leonard, I [2 ,3 ]
机构：
[1] Ohio State Univ, Coll Med, Dept Internal Med, Comprehens Canc Ctr,Div Hematol, Columbus, OH 43210 USA
[2] Harvard Med Sch, Boston Childrens Hosp, Harvard Stem Cell Inst, Stem Cell Program,Howard Hughes Med Inst, Boston, MA USA
[3] Harvard Med Sch, Boston Childrens Hosp, Harvard Stem Cell Inst, Div Hematol Oncol,Howard Hughes Med Inst, Boston, MA USA
来源：
BLOOD | 2018年 / 132卷 / 13期
基金：
美国国家卫生研究院;
关键词：
EMBRYONIC STEM-CELLS; COLONY-FORMING CELLS; HEMATOPOIETIC STEM; YOLK-SAC; HAEMOGENIC ENDOTHELIUM; AORTIC ENDOTHELIUM; HOMEOBOX GENES; VASCULAR NICHE; BLOOD-CELLS; ES CELLS;
D O I：
10.1182/blood-2018-04-784140
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Generating a hematopoietic stem cell (HSC) in vitro from nonhematopoietic tissue has been a goal of experimental hematologists for decades. Until recently, no in vitro-derived cell has closely demonstrated the full lineage potential and self-renewal capacity of a true HSC. Studies revealing stem cell ontogeny from embryonic mesoderm to hemogenic endothelium to HSC provided the key to inducing HSC-like cells in vitro from a variety of cell types. Here we review the path to this discovery and discuss the future of autologous transplantation with in vitro-derived HSCs as a therapeutic modality.
引用
收藏
页码：1372 / 1378
页数：7
相关论文
共 94 条
[1]   Inherited bone marrow failure syndromes: considerations pre- and posttransplant [J].
Alter, Blanche P. .
BLOOD, 2017, 130 (21) :2257-2264
[2]   Direct Reprogramming of Murine Fibroblasts to Hematopoietic Progenitor Cells [J].
Batta, Kiran ;
Florkowska, Magdalena ;
Kouskoff, Valerie ;
Lacaud, Georges .
CELL REPORTS, 2014, 9 (05) :1871-1884
[3]   Haematopoietic stem cells derive directly from aortic endothelium during development [J].
Bertrand, Julien Y. ;
Chi, Neil C. ;
Santoso, Buyung ;
Teng, Shutian ;
Stainier, Didier Y. R. ;
Traver, David .
NATURE, 2010, 464 (7285) :108-U120
[4]   CXCR1 remodels the vascular niche to promote hematopoietic stem and progenitor cell engraftment [J].
Blaser, Bradley W. ;
Moore, Jessica L. ;
Hagedorn, Elliott J. ;
Li, Brian ;
Riquelme, Raquel ;
Lichtig, Asher ;
Yang, Song ;
Zhou, Yi ;
Tamplin, Owen J. ;
Binder, Vera ;
Zon, Leonard I. .
JOURNAL OF EXPERIMENTAL MEDICINE, 2017, 214 (04) :1011-1027
[5]   In vivo imaging of haematopoietic cells emerging from the mouse aortic endothelium [J].
Boisset, Jean-Charles ;
van Cappellen, Wiggert ;
Andrieu-Soler, Charlotte ;
Galjart, Niels ;
Dzierzak, Elaine ;
Robin, Catherine .
NATURE, 2010, 464 (7285) :116-U131
[6]   Aryl Hydrocarbon Receptor Antagonists Promote the Expansion of Human Hematopoietic Stem Cells [J].
Boitano, Anthony E. ;
Wang, Jian ;
Romeo, Russell ;
Bouchez, Laure C. ;
Parker, Albert E. ;
Sutton, Sue E. ;
Walker, John R. ;
Flaveny, Colin A. ;
Perdew, Gary H. ;
Denison, Michael S. ;
Schultz, Peter G. ;
Cooke, Michael P. .
SCIENCE, 2010, 329 (5997) :1345-1348
[7]   Intra-BM injection to enhance engraftment after myeloablative umbilical cord blood transplantation with two partially HLA-matched units [J].
Brunstein, C. G. ;
Barker, J. N. ;
Weisdorf, D. J. ;
DeFor, T. D. ;
McKenna, D. ;
Chong, S. Y. ;
Miller, J. S. ;
McGlave, P. B. ;
Wagner, J. E. .
BONE MARROW TRANSPLANTATION, 2009, 43 (12) :935-940
[8]   Cytokines and BMP-4 promote hematopoietic differentiation of human embryonic stem cells [J].
Chadwick, K ;
Wang, LS ;
Li, L ;
Menendez, P ;
Murdoch, B ;
Rouleau, A ;
Bhatia, M .
BLOOD, 2003, 102 (03) :906-915
[9]   Zebrafish Blood Stem Cells [J].
Chen, Aye T. ;
Zon, Leonard I. .
JOURNAL OF CELLULAR BIOCHEMISTRY, 2009, 108 (01) :35-42
[10]   Functional characterization of B lymphocytes generated in vitro from embryonic stem cells [J].
Cho, SK ;
Webber, TD ;
Carlyle, JR ;
Nakano, T ;
Lewis, SM ;
Zúñiga-Pflücker, JC .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (17) :9797-9802
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