The neuropeptide vasoactive intestinal peptide: direct effects on immune cells and involvement in inflammatory and autoimmune diseases

被引：94
作者：
Ganea, D. [1 ]
Hooper, K. M. [1 ]
Kong, W. [1 ]
机构：
[1] Temple Univ, Dept Microbiol & Immunol, Sch Med, Philadelphia, PA 19140 USA
来源：
ACTA PHYSIOLOGICA | 2015年 / 213卷 / 02期
关键词：
autoimmune diseases; innate immunity; neuropeptides; T-cell differentiation; tolerogenic dendritic cells; vasoactive intestinal peptide; CYCLASE-ACTIVATING POLYPEPTIDE; COLLAGEN-INDUCED ARTHRITIS; CENTRAL-NERVOUS-SYSTEM; RHEUMATOID SYNOVIAL FIBROBLASTS; TOLEROGENIC DENDRITIC CELLS; REGULATORY T-CELLS; IN-VIVO; CHEMOKINE PRODUCTION; TRANSGENIC MICE; MULTIPLE-SCLEROSIS;
D O I：
10.1111/apha.12427
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Neuropeptides represent an important category of endogenous contributors to the establishment and maintenance of immune deviation in the immune-privileged organs such as the CNS and in the control of acute inflammation in the peripheral immune organs. Vasoactive intestinal peptide (VIP) is a major immunoregulatory neuropeptide widely distributed in the central and peripheral nervous system. In addition to neurones, VIP is synthesized by immune cells which also express VIP receptors. Here, we review the current information on VIP production and VIP-receptor-mediated effects in the immune system, the role of endogenous and exogenous VIP in inflammatory and autoimmune disorders and the present and future VIP therapeutic approaches.
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收藏
页码：442 / 452
页数：11
相关论文
共 98 条
[1]   VIP Deficient Mice Exhibit Resistance to Lipopolysaccharide Induced Endotoxemia with an Intrinsic Defect in Proinflammatory Cellular Responses [J].
Abad, Catalina ;
Tan, Yossan-Var ;
Cheung-Lau, Gardenia ;
Nobuta, Hiroko ;
Waschek, James A. .
PLOS ONE, 2012, 7 (05)
[2]   Vasoactive intestinal peptide loss leads to impaired CNS parenchymal T-cell infiltration and resistance to experimental autoimmune encephalomyelitis [J].
Abad, Catalina ;
Tan, Yossan-Var ;
Lopez, Robert ;
Nobuta, Hiroko ;
Dong, Hongmei ;
Phan, Phu ;
Feng, Ji-Ming ;
Campagnoni, Anthony T. ;
Waschek, James A. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (45) :19555-19560
[3]   VIP IN CEREBROSPINAL-FLUID OF PATIENTS WITH MULTIPLE-SCLEROSIS [J].
ANDERSEN, O ;
FAHRENKRUG, J ;
WIKKELSO, C ;
JOHANSSON, BB .
PEPTIDES, 1984, 5 (02) :435-437
[4]   VIP balances innate and adaptive immune responses induced by specific stimulation of TLR2 and TLR4 [J].
Arranz, Alicia ;
Juarranz, Yasmina ;
Leceta, Javier ;
Gomariz, Rosa P. ;
Martinez, Carmen .
PEPTIDES, 2008, 29 (06) :948-956
[5]   Vasoactive intestinal polypeptide mediates circadian rhythmicity and synchrony in mammalian clock neurons [J].
Aton, SJ ;
Colwell, CS ;
Harmar, AJ ;
Waschek, J ;
Herzog, ED .
NATURE NEUROSCIENCE, 2005, 8 (04) :476-483
[6]   VIPase autoantibodies in Fas-defective mice and patients with autoimmune disease [J].
Bangale, Y ;
Karle, S ;
Planque, S ;
Zhou, YX ;
Taguchi, H ;
Nishiyama, Y ;
Li, L ;
Kalaga, R ;
Paul, S .
FASEB JOURNAL, 2003, 17 (06) :628-635
[7]   The significance of vasoactive intestinal polypeptide (VIP) in immunomodulation [J].
Bellinger, DL ;
Lorton, D ;
Brouxhon, S ;
Felten, S ;
Felten, DL .
ADVANCES IN NEUROIMMUNOLOGY, 1996, 6 (01) :5-27
[8]   Vasoactive intestinal polypeptide (VIP) innervation of rat spleen, thymus, and lymph nodes [J].
Bellinger, DL ;
Lorton, D ;
Horn, L ;
Brouxhon, S ;
Felten, SY ;
Felten, DL .
PEPTIDES, 1997, 18 (08) :1139-1149
[9]  
BLOOM SR, 1973, LANCET, V2, P14
[10]   Foxp3+Regulatory T Cells of Psoriasis Patients Easily Differentiate into IL-17A-Producing Cells and Are Found in Lesional Skin [J].
Bovenschen, H. Jorn ;
van de Kerkhof, Peter C. ;
van Erp, Piet E. ;
Woestenenk, Rob ;
Joosten, Irma ;
Koenen, Hans J. P. M. .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2011, 131 (09) :1853-1860
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