Ameloblastoma: A succinct review of the classification, genetic understanding and novel molecular targeted therapies

被引：34

作者：

Shi, Hongyi Adrian ^{[1
]}

Ng, Chee Wee Benjamin ^{[1
]}

Kwa, Chong Teck ^{[1
]}

Sim, Qiu Xia Chelsia ^{[1
]}

机构：

[1] Natl Dent Ctr Singapore, Dept Oral & Maxillofacial Surg, Singapore, Singapore

来源：

SURGEON-JOURNAL OF THE ROYAL COLLEGES OF SURGEONS OF EDINBURGH AND IRELAND | 2021年 / 19卷 / 04期

关键词：

Ameloblastoma; Odontogenic tumours; Immunohistochemistry; BRAF; Molecular targeted therapy; UNICYSTIC AMELOBLASTOMA; METASTATIC MELANOMA; MUTATIONS; DABRAFENIB; VEMURAFENIB; SURVIVAL; TUMORS;

D O I：

10.1016/j.surge.2020.06.009

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Ameloblastomas are benign but locally invasive neoplasms which may grow to massive proportions and cause significant morbidity. Although some types of ameloblastoma can be treated predictably with aggressive surgical treatment, recurrent ameloblastoma and metastasising ameloblastoma are still difficult to treat. Recent studies have identified recurrent somatic and activating mutations in the mitogen-activated protein kinase (MAPK) and sonic hedgehog (SHH) signalling pathways in ameloblastoma. This development provided a possibility that molecular targeted therapies can be used as neoadjuvant treatment. In this review, we provide a summary of the latest WHO classification of ameloblastoma, the current understanding of genetic mutations and novel molecular targeted therapies arising from the recent developments. (C) 2020 Royal College of Surgeons of Edinburgh (Scottish charity number SC005317) and Royal College of Surgeons in Ireland. Published by Elsevier Ltd. All rights reserved.

引用

页码：238 / 243

页数：6

共 47 条

[1] Recurrence rate following treatment for primary multicystic ameloblastoma: systematic review and meta-analysis [J].

Almeida, R. de A. C. ;

Andrade, E. S. de S. ;

Barbalho, J. C. ;

Vajgel, A. ;

Vasconcelos, B. C. do E. .

INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 2016, 45 (03) :359-367

[2] Metastatic ameloblastoma responding to combination chemotherapy: Case report and review of the literature [J].

Amzerin M. ;

Fadoukhair Z. ;

Belbaraka R. ;

Iraqui M. ;

Boutayeb S. ;

M'Rabti H. ;

Kebdani T. ;

Hassouni K. ;

Benjaafar N. ;

El Gueddari B.K. ;

Errihani H. .

Journal of Medical Case Reports, 5 (1)

[3] FDG-PET is a good biomarker of both early response and acquired resistance in BRAFV600 mutant melanomas treated with vemurafenib and the MEK inhibitor GDC-0973 [J].

Baudy, Andreas R. ;

Dogan, Taner ;

Flores-Mercado, Judith E. ;

Hoeflich, Klaus P. ;

Su, Fei ;

van Bruggen, Nicholas ;

Williams, Simon-Peter .

EJNMMI RESEARCH, 2012, 2

[4] Persistent response to vemurafenib in metastatic ameloblastoma with BRAF mutation: a case report [J].

Broudic-Guibert, Morgane ;

Blay, Jean-Yves ;

Vazquez, Lea ;

Evrard, Alexandre ;

Karanian, Marie ;

Taieb, Sophie ;

Hoog-Labouret, Natalie ;

Oukhatar, Celine Mahier Ait ;

Boustany-Grenier, Rania ;

Arnaud, Antoine .

JOURNAL OF MEDICAL CASE REPORTS, 2019, 13 (01) :245

[5]

Brown Noah A, 2015, Biomark Cancer, V7, P19, DOI 10.4137/BIC.S29329

[6] Activating FGFR2-RAS-BRAF Mutations in Ameloblastoma [J].

Brown, Noah A. ;

Rolland, Delphine ;

McHugh, Jonathan B. ;

Weigelin, Helmut C. ;

Zhao, Lili ;

Lim, Megan S. ;

Elenitoba-Johnson, Kojo S. J. ;

Betz, Bryan L. .

CLINICAL CANCER RESEARCH, 2014, 20 (21) :5517-5526

[7] Enabling Precision Medicine for Rare Head and Neck Tumors: The Example of BRAF/MEK Targeting in Patients With Metastatic Ameloblastoma [J].

Brunet, Maxime ;

Khalifa, Emmanuel ;

Italiano, Antoine .

FRONTIERS IN ONCOLOGY, 2019, 9

[8] BRAF p.V600E mutations are not unique to ameloblastoma and are shared by other odontogenic tumors with ameloblastic morphology [J].

Brunner, P. ;

Bihl, M. ;

Jundt, G. ;

Baumhoer, D. ;

Hoeller, S. .

ORAL ONCOLOGY, 2015, 51 (10) :E77-E78

[9] Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation [J].

Chapman, Paul B. ;

Hauschild, Axel ;

Robert, Caroline ;

Haanen, John B. ;

Ascierto, Paolo ;

Larkin, James ;

Dummer, Reinhard ;

Garbe, Claus ;

Testori, Alessandro ;

Maio, Michele ;

Hogg, David ;

Lorigan, Paul ;

Lebbe, Celeste ;

Jouary, Thomas ;

Schadendorf, Dirk ;

Ribas, Antoni ;

O'Day, Steven J. ;

Sosman, Jeffrey A. ;

Kirkwood, John M. ;

Eggermont, Alexander M. M. ;

Dreno, Brigitte ;

Nolop, Keith ;

Li, Jiang ;

Nelson, Betty ;

Hou, Jeannie ;

Lee, Richard J. ;

Flaherty, Keith T. ;

McArthur, Grant A. .

NEW ENGLAND JOURNAL OF MEDICINE, 2011, 364 (26) :2507-2516

[10] Mutations of the BRAF gene in human cancer [J].

Davies, H ;

Bignell, GR ;

Cox, C ;

Stephens, P ;

Edkins, S ;

Clegg, S ;

Teague, J ;

Woffendin, H ;

Garnett, MJ ;

Bottomley, W ;

Davis, N ;

Dicks, N ;

Ewing, R ;

Floyd, Y ;

Gray, K ;

Hall, S ;

Hawes, R ;

Hughes, J ;

Kosmidou, V ;

Menzies, A ;

Mould, C ;

Parker, A ;

Stevens, C ;

Watt, S ;

Hooper, S ;

Wilson, R ;

Jayatilake, H ;

Gusterson, BA ;

Cooper, C ;

Shipley, J ;

Hargrave, D ;

Pritchard-Jones, K ;

Maitland, N ;

Chenevix-Trench, G ;

Riggins, GJ ;

Bigner, DD ;

Palmieri, G ;

Cossu, A ;

Flanagan, A ;

Nicholson, A ;

Ho, JWC ;

Leung, SY ;

Yuen, ST ;

Weber, BL ;

Siegler, HF ;

Darrow, TL ;

Paterson, H ;

Marais, R ;

Marshall, CJ ;

Wooster, R .

NATURE, 2002, 417 (6892) :949-954

← 1 2 3 4 5 →