Development and descent of the testis in relation to cryptorchidism

被引：59
作者：
Virtanen, Helena E.
Cortes, Dina
Meyts, Ewa Rajpert-De
Ritzen, E. Martin
Nordenskjold, Agneta
Skakkebaek, Niels E.
Toppari, Jorma
机构：
[1] Univ Turku, Dept Physiol, FIN-20520 Turku, Finland
[2] Univ Turku, Dept Paediat, FIN-20520 Turku, Finland
[3] Glostrup Univ Hosp, Dept Paediat, DK-2600 Glostrup, Denmark
[4] Rigshosp, Dept Paediat Surg, DK-2100 Copenhagen, Denmark
[5] Karolinska Inst, Dept Woman & Child Hlth, Paediat Endocrinol Unit, S-10401 Stockholm, Sweden
[6] Karolinska Univ Hosp, Astrid Lindgren Children Hosp, Dept Paediat Surg, S-10691 Stockholm, Sweden
[7] Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden
[8] Rigshosp, Univ Dept Growth & Reprod, DK-2100 Copenhagen, Denmark
来源：
ACTA PAEDIATRICA | 2007年 / 96卷 / 05期
关键词：
cryptorchidism; histology; testicular descent;
D O I：
10.1111/j.1651-2227.2007.00244.x
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
The testis descends in two phases. Animal studies suggest, that the transabdominal descent of the testis depends on the insulin-like hormone 3 (INSL3). Androgens are important in the inguinoscrotal testicular descent in animals and humans. In general, the cause of cryptorchidism is unknown and the aetiology is possibly multifactorial. Histological changes in cryptorchid testes demonstrate disturbed development. Conclusion: Since testicular descent is regulated by testis-derived hormones, cryptorchidism may reflect a functional defect of the testis.
引用
收藏
页码：622 / 627
页数：6
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