Mechanics of microtubules

被引：191

作者：

Hawkins, Taviare ^{[2
]}

Mirigian, Matthew ^{[1
]}

Yasar, M. Selcuk ^{[1
]}

Ross, Jennifer L. ^{[1
]}

机构：

[1] Univ Massachusetts, Dept Phys, 302 Hasbrouck Lab, Amherst, MA 01003 USA

[2] Mt Holyoke Coll, Dept Phys, S Hadley, MA USA

来源：

JOURNAL OF BIOMECHANICS | 2010年 / 43卷 / 01期

基金：

美国国家科学基金会;

关键词：

Flexural rigidity; Flexibility; Microtubule bundle; Cytoskeletal network; FLEXURAL RIGIDITY; THERMAL FLUCTUATIONS; DYNAMIC INSTABILITY; PERSISTENCE LENGTH; INDIVIDUAL MICROTUBULES; GROWING MICROTUBULES; SINGLE-MICROTUBULE; ACTIN-FILAMENTS; PROTEINS; COMPLEX;

D O I：

10.1016/j.jbiomech.2009.09.005

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Microtubules are rigid cytoskeletal filaments, and their mechanics affect cell morphology and cellular processes. For instance, microtubules for the support structures for extended morphologies, such as axons and cilia. Further, microtubules act as tension rods to pull apart chromosomes during cellular division. Unlike other cytoskeletal filaments (e.g., actin) that work as large networks, microtubules work individually or in small groups, so their individual mechanical properties are quite important to their cellular function. In this review, we explore the past work on the mechanics of individual microtubules, which have. been studied for over a quarter of a century. We also present some prospective on future endeavors to determine the molecular mechanisms that control microtubule rigidity. Published by Elsevier Ltd.

引用

页码：23 / 30

页数：8

共 67 条

[1]

AMOS LA, 1974, J CELL SCI, V14, P523

[2]

Amos Linda A, 2007, Methods Mol Med, V137, P65, DOI 10.1007/978-1-59745-442-1_5

[3] The Dam1 kinetochore complex harnesses microtubule dynamics to produce force and movement [J].

Asbury, Charles L. ;

Gestaut, Daniel R. ;

Powers, Andrew F. ;

Franck, Andrew D. ;

Davis, Trisha N. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (26) :9873-9878

[4] TENSION, MICROTUBULE REARRANGEMENTS, AND THE PROPER DISTRIBUTION OF CHROMOSOMES IN MITOSIS [J].

AULT, JG ;

NICKLAS, RB .

CHROMOSOMA, 1989, 98 (01) :33-39

[5]

BABA SA, 1972, J EXP BIOL, V56, P459

[6] Analysis of microtubule curvature [J].

Bicek, Andrew D. ;

Tuezel, Erkan ;

Kroll, Daniel M. ;

Odde, David J. .

CELL MECHANICS, 2007, 83 :237-268

[7] Bending dynamics of fluctuating biopolymers probed by automated high-resolution filament tracking [J].

Brangwynne, Clifford P. ;

Koenderink, Gijsje H. ;

Barry, Ed ;

Dogic, Zvonimir ;

MacKintosh, Frederick C. ;

Weitz, David A. .

BIOPHYSICAL JOURNAL, 2007, 93 (01) :346-359

[8] Microtubules can bear enhanced compressive loads in living cells because of lateral reinforcement [J].

Brangwynne, Clifford P. ;

MacKintosh, Frederick C. ;

Kumar, Sanjay ;

Geisse, Nicholas A. ;

Talbot, Jennifer ;

Mahadevan, L. ;

Parker, Kevin K. ;

Ingber, Donald E. ;

Weitz, David A. .

JOURNAL OF CELL BIOLOGY, 2006, 173 (05) :733-741

[9] XMAP215 is a processive microtubule polymerase [J].

Brouhard, Gary J. ;

Stear, Jeffrey H. ;

Noetzel, Tim L. ;

Al-Bassam, Jawdat ;

Kinoshita, Kazuhisa ;

Harrison, Stephen C. ;

Howard, Jonathon ;

Hyman, Anthony A. .

CELL, 2008, 132 (01) :79-88

[10] REGULATION OF MICROTUBULE DYNAMIC INSTABILITY [J].

CASSIMERIS, L .

CELL MOTILITY AND THE CYTOSKELETON, 1993, 26 (04) :275-281

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