Significant Inactivation of SARS-CoV-2 In Vitro by a Green Tea Catechin, a Catechin-Derivative, and Black Tea Galloylated Theaflavins

被引：59

作者：

Ohgitani, Eriko ^{[1
]}

Shin-Ya, Masaharu ^{[1
]}

Ichitani, Masaki ^{[2
]}

Kobayashi, Makoto ^{[2
]}

Takihara, Takanobu ^{[2
]}

Kawamoto, Masaya ^{[1
]}

Kinugasa, Hitoshi ^{[2
]}

Mazda, Osam ^{[1
]}

机构：

[1] Kyoto Prefectural Univ Med, Dept Immunol, Kamigyo Ku, Kyoto 6028566, Japan

[2] ITO EN Ltd, Cent Res Inst, Shizuoka 4210516, Japan

来源：

MOLECULES | 2021年 / 26卷 / 12期

关键词：

novel coronavirus; COVID-19; tea; catechin; theaflavin; polyphenol; POLYPHENOL (-)-EPIGALLOCATECHIN-3-GALLATE; BIOAVAILABILITY; STABILITY;

D O I：

10.3390/molecules26123572

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Potential effects of tea and its constituents on SARS-CoV-2 infection were assessed in vitro. Infectivity of SARS-CoV-2 was decreased to 1/100 to undetectable levels after a treatment with black tea, green tea, roasted green tea, or oolong tea for 1 min. An addition of (-) epigallocatechin gallate (EGCG) significantly inactivated SARS-CoV-2, while the same concentration of theasinensin A (TSA) and galloylated theaflavins including theaflavin 3,3 '-di-O-gallate (TFDG) had more remarkable anti-viral activities. EGCG, TSA, and TFDG at 1 mM, 40 mu M, and 60 mu M, respectively, which are comparable to the concentrations of these compounds in tea beverages, significantly reduced infectivity of the virus, viral RNA replication in cells, and secondary virus production from the cells. EGCG, TSA, and TFDG significantly inhibited interaction between recombinant ACE2 and RBD of S protein. These results suggest potential usefulness of tea in prevention of person-to-person transmission of the novel coronavirus.

引用

页数：12

共 28 条

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