Reliability of rapid testing for hepatitis B in a region of high HIV endemicity

被引：18

作者：

Davies, J. ^{[1
]}

van Oosterhout, J. J. G. ^{[2
]}

Nyirenda, M. ^{[2
]}

Bowden, J. ^{[3
]}

Moore, E. ^{[2
]}

Hart, I. J. ^{[3
]}

Zijlstra, E. E. ^{[2
]}

Chaponda, M. ^{[1
,2
]}

Faragher, B. ^{[4
]}

Beeching, N. J. ^{[1
,4
]}

Beadsworth, M. B. J. ^{[1
,2
,4
]}

机构：

[1] Royal Liverpool Univ Hosp, Trop & Infect Dis Unit, Liverpool L7 8XP, Merseyside, England

[2] Coll Med, Dept Med, Blantyre, Malawi

[3] Royal Liverpool Univ Hosp, Liverpool Specialist Virol Ctr, Liverpool L7 8XP, Merseyside, England

[4] Univ Liverpool, Liverpool Sch Trop Med, Liverpool L3 5QA, Merseyside, England

来源：

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE | 2010年 / 104卷 / 02期

关键词：

Hepatitis B; HIV; Co-infection; Diagnosis; Point-of-care test; Malawi; SURFACE-ANTIGEN; VIRUS; INFECTION; COINFECTION;

D O I：

10.1016/j.trstmh.2009.10.010

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Hepatitis B (HBV) and HIV co-infection is common in resource-poor settings. A recent study from Malawi revealed poor correlation between hepatitis B surface antigen (HBsAg) point-of-care tests and reference tests in patients co-infected with HIV. We studied a cohort of 300 Malawian adults entering a treatment programme for HIV. Sera were tested for HBsAg first using the Determine rapid test and re-tested using a commercial enzyme immunoassay (EIA). All tests were done under optimal conditions in Liverpool, UK. Sera from all 25 patients positive for HBsAg using the rapid test and from 50 who were negative, were re-tested using the EIA, with complete concordance of results. The K correlation was 1, specificity 100% (93-100%) and sensitivity 100% (86-100%) compared to the reference test. Patients had advanced immune Suppression (mean CD4 = 175 cells x 10(6)/l). In a non-field setting, the results of point-of-care Determine rapid hepatitis B tests appear reliable in patients with HIV-1 co-infection. (C) 2009 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.

引用

页码：162 / 164

页数：3

共 13 条

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