Addition of tetraethylthiuram disulfide to antimony(III) iodide; synthesis, characterization and biological activity

被引：34

作者：

Urgut, O. S. ^{[1
]}

Ozturk, I. I. ^{[1
]}

Banti, C. N. ^{[2
]}

Kourkoumelis, N. ^{[3
]}

Manoli, M. ^{[4
]}

Tasiopoulos, A. J. ^{[4
]}

Hadjikakou, S. K. ^{[2
]}

机构：

[1] Namik Kemal Univ, Dept Chem, TR-59030 Tekirdag, Turkey

[2] Univ Ioannina, Dept Chem, Sect Inorgan & Analyt Chem, GR-45110 Ioannina, Greece

[3] Univ Ioannina, Sch Med, Med Phys Lab, GR-45110 Ioannina, Greece

[4] Univ Cyprus, Dept Chem, CY-1678 Nicosia, Cyprus

来源：

INORGANICA CHIMICA ACTA | 2016年 / 443卷

关键词：

Antimony(III) complexes; Crystal structures; N; N-diethylcarbamodithioic acid; Cytotoxicity; Structure Activity Relationship (SAR); STRUCTURAL-CHARACTERIZATION; IN-VITRO; MOLECULAR-STRUCTURE; DIPHENYLANTIMONY(III) DERIVATIVES; COORDINATION CHEMISTRY; CRYSTAL-STRUCTURE; THIURAM SULFIDES; HALIDE-COMPLEXES; DITHIOCARBAMATE; BISMUTH(III);

D O I：

10.1016/j.ica.2015.12.028

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Three new antimony(III) iodide complexes with the N,N-diethylcarbamodithioic acid of formulae {[(SbI(Et2DTC)(2))(I-2)](n)} (1), {[(Sb(Et2DTC)(2))(4) (SbI6) (I-3)](n)} (2) and {[SbI(Et2DTC)(2)](2)} (3), (Et2DTCH: N,N-diethylcarbamodithioic acid, C5H11NS2) were synthesized from the reaction of antimony(III) iodide with tetraethylthiuram disulfide in 1: 1 stoichiometry. The complexes 1-3 were characterized by melting point, elemental analysis, FT-IR spectroscopy, Raman spectroscopy, H-1, C-13 NMR spectroscopy and Thermal Gravimetry-Differential Thermal Analysis (TG-DTA). Moreover, crystal structures of complexes 1-3 were determinated with single crystal X-ray diffraction analysis. Complexes 1-3 derived from ligand reduction with concomitant degradation of the tetraethylthiuram disulfide to dithiocarbamates. Complexes 1 and 2 are polymer but complex 3 is dimmer. Complex 1 consists of two residues, [SbI (Et2DTC)(2)] and [I-2], while 2 consists of three residues, four cationic [Sb(Et(2)dtc)(2)](+), one [SbI6](3-) and one [I-3](-) counter anion. Complexes 1-3 were evaluated for their in vitro cytotoxic activity against human breast adenocarcinoma (MCF-7) and human cervix adenocarcinoma (HeLa) cells. Structure Activity Relationship (SAR) studies reveal that the high activity of the complexes is positively correlated with the low H-all atoms intermolecular contacts. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：141 / 150

页数：10

共 73 条

[1] CRYSTAL AND MOLECULAR-STRUCTURE AND KINETICS OF LIGAND-EXCHANGE OF TRIS(N,N-DIMETHYLDITHIOCARBAMATO)THALLIUM(III) [J].

ABRAHAMSON, H ;

HEIMAN, JR ;

PIGNOLET, LH .

INORGANIC CHEMISTRY, 1975, 14 (09) :2070-2075

[2]

[Anonymous], CRYSALIS RED VERS 1

[3]

[Anonymous], 2006, CRYS CCD CRYS RED VE

[4] Tris(N-cyclohexyl-N-methyldithiocarbamato-S)-antimony(III) [J].

Baba, I ;

Ibrahim, S ;

Farina, Y ;

Othman, AH ;

Razak, IA ;

Fun, HK ;

Ng, SW .

ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2001, 57 :M39-M40

[5]

BARA A, 1991, ANTICANCER RES, V11, P1651

[6]

Batsanov S.S., 2001, INORG MAT, V37, P1031

[7] Van der Waals radii of elements [J].

Batsanov, SS .

INORGANIC MATERIALS, 2001, 37 (09) :871-885

[8]

Beurskens P.T., 1972, J CRYST MOL STRUCT, V2, P183

[9]

Butterfield E. J., 1991, KIRK ORTMER ENCY CHE

[10] Synthetic, spectral, thermal and antimicrobial studies on some bis(N,N′-dialkyldithiocarbamato) antimony(III) alkylenedithiophosphates [J].

Chauhan, H. P. S. ;

Singh, U. P. .

APPLIED ORGANOMETALLIC CHEMISTRY, 2007, 21 (10) :880-889

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