Chemokine receptor 2 (CCR2) in atherosclerosis, infectious diseases, and regulation of T-cell polarization

被引：75
作者：
Charo, IF
Peters, W
机构：
[1] Univ Calif San Francisco, Gladstone Inst Cardiovasc Dis, San Francisco, CA 94141 USA
[2] Univ Calif San Francisco, Cardiovasc Res Inst, San Francisco, CA 94143 USA
[3] Univ Calif San Francisco, Dept Med, San Francisco, CA USA
来源：
MICROCIRCULATION | 2003年 / 10卷 / 3-4期
关键词：
chemokines; CCR2; MCP-1; atherosclerosis; interferon gamma; MONOCYTE CHEMOATTRACTANT PROTEIN-1; RECEPTOR-DEFICIENT MICE; CORONARY-ARTERY DISEASE; SMOOTH-MUSCLE CELLS; CHEMOKINE RECEPTOR; OXIDIZED LDL; CRYPTOCOCCUS-NEOFORMANS; REDUCES ATHEROSCLEROSIS; CHEMOTACTIC PROTEIN-1; FIRM ADHESION;
D O I：
10.1038/sj.mn.7800191
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Infiltration of tissues by monocyte-derived macrophages is a prominent component of a wide-range of diseases, including atherosclerosis, glomerulonephritis, encephalitis, infectious diseases, and virtually all syndromes characterized by chronic inflammation. The molecular signals responsible for this directed migration are incompletely understood, but members of the chemokine family, especially the monocyte chemoattractant proteins (MCPs) (MCP-1 to MCP-5) are emerging as key players. Cells that respond to the MCPs do so because they express chemokine receptor 2 (CCR2), the cognate receptor. This review will summarize evidence supporting a key role for CCR2 in the pathogenesis of atherosclerosis, infections with intracellular pathogens, and regulation of the type I adaptive immune response.
引用
收藏
页码：259 / 264
页数：6
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