Chemokine receptor 2 (CCR2) in atherosclerosis, infectious diseases, and regulation of T-cell polarization

被引：75
作者：
Charo, IF
Peters, W
机构：
[1] Univ Calif San Francisco, Gladstone Inst Cardiovasc Dis, San Francisco, CA 94141 USA
[2] Univ Calif San Francisco, Cardiovasc Res Inst, San Francisco, CA 94143 USA
[3] Univ Calif San Francisco, Dept Med, San Francisco, CA USA
来源：
MICROCIRCULATION | 2003年 / 10卷 / 3-4期
关键词：
chemokines; CCR2; MCP-1; atherosclerosis; interferon gamma; MONOCYTE CHEMOATTRACTANT PROTEIN-1; RECEPTOR-DEFICIENT MICE; CORONARY-ARTERY DISEASE; SMOOTH-MUSCLE CELLS; CHEMOKINE RECEPTOR; OXIDIZED LDL; CRYPTOCOCCUS-NEOFORMANS; REDUCES ATHEROSCLEROSIS; CHEMOTACTIC PROTEIN-1; FIRM ADHESION;
D O I：
10.1038/sj.mn.7800191
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Infiltration of tissues by monocyte-derived macrophages is a prominent component of a wide-range of diseases, including atherosclerosis, glomerulonephritis, encephalitis, infectious diseases, and virtually all syndromes characterized by chronic inflammation. The molecular signals responsible for this directed migration are incompletely understood, but members of the chemokine family, especially the monocyte chemoattractant proteins (MCPs) (MCP-1 to MCP-5) are emerging as key players. Cells that respond to the MCPs do so because they express chemokine receptor 2 (CCR2), the cognate receptor. This review will summarize evidence supporting a key role for CCR2 in the pathogenesis of atherosclerosis, infections with intracellular pathogens, and regulation of the type I adaptive immune response.
引用
收藏
页码：259 / 264
页数：6
相关论文
共 43 条
[1]   Monocyte chemoattractant protein-1 accelerates atherosclerosis in apolipoprotein E-deficient mice [J].
Aiello, RJ ;
Bourassa, PAK ;
Lindsey, S ;
Weng, WF ;
Natoli, E ;
Rollins, BJ ;
Milos, PM .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1999, 19 (06) :1518-1525
[2]   A new class of membrane-bound chemokine with a CX(3)C motif [J].
Bazan, JF ;
Bacon, KB ;
Hardiman, G ;
Wang, W ;
Soo, K ;
Rossi, D ;
Greaves, DR ;
Zlotnik, A ;
Schall, TJ .
NATURE, 1997, 385 (6617) :640-644
[3]   A leukocyte homologue of the IL-8 receptor CXCR-2 mediates the accumulation of macrophages in atherosclerotic lesions of LDL receptor-deficient mice [J].
Boisvert, WA ;
Santiago, R ;
Curtiss, LK ;
Terkeltaub, RA .
JOURNAL OF CLINICAL INVESTIGATION, 1998, 101 (02) :353-363
[4]   Decreased lesion formation in CCR2-/- mice reveals a role for chemokines in the initiation of atherosclerosis [J].
Boring, L ;
Gosling, J ;
Cleary, M ;
Charo, IF .
NATURE, 1998, 394 (6696) :894-897
[5]   MINIMALLY MODIFIED LOW-DENSITY-LIPOPROTEIN INDUCES MONOCYTE CHEMOTACTIC PROTEIN-1 IN HUMAN ENDOTHELIAL-CELLS AND SMOOTH-MUSCLE CELLS [J].
CUSHING, SD ;
BERLINER, JA ;
VALENTE, AJ ;
TERRITO, MC ;
NAVAB, M ;
PARHAMI, F ;
GERRITY, R ;
SCHWARTZ, CJ ;
FOGELMAN, AM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (13) :5134-5138
[6]  
Dawson TC, 1999, ATHEROSCLEROSIS, V143, P205
[7]   Anti-monocyte chemoattractant protein-1 gene therapy inhibits vascular remodeling in rats: blockade of MCP-1 activity after intramuscular transfer of a mutant gene inhibits vascular remodeling induced by chronic blockade of NO synthesis [J].
Egashira, K ;
Koyanagi, M ;
Kitamoto, S ;
Ni, WH ;
Kataoka, C ;
Morishita, R ;
Kaneda, Y ;
Akiyama, C ;
Nishida, KI ;
Sueishi, K ;
Takeshita, A .
FASEB JOURNAL, 2000, 14 (13) :1974-1978
[8]   STUDIES OF HYPERCHOLESTEROLEMIA IN THE NONHUMAN PRIMATE .1. CHANGES THAT LEAD TO FATTY STREAK FORMATION [J].
FAGGIOTTO, A ;
ROSS, R ;
HARKER, L .
ARTERIOSCLEROSIS, 1984, 4 (04) :323-340
[9]   Fractalkine and CX3CR1 mediate a novel mechanism of leukocyte capture, firm adhesion, and activation under physiologic flow [J].
Fong, AM ;
Robinson, LA ;
Steeber, DA ;
Tedder, TF ;
Yoshie, O ;
Imai, T ;
Patel, DD .
JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 188 (08) :1413-1419
[10]  
GERRITY RG, 1980, ARTERY, V8, P208
12345