New water-soluble copper (II) complexes including 4,7-dimethyl-1,10-phenanthroline and L-tyrosine: Synthesis, characterization, DNA interactions and cytotoxicities

被引：26

作者：

Inci, Duygu ^{[1
]}

Aydin, Rahmiye ^{[1
]}

Yilmaz, Dilek ^{[2
]}

Genckal, Hasene Mutlu ^{[1
]}

Vatan, Ozgur ^{[2
]}

Cinkilic, Nilufer ^{[2
]}

Zorlu, Yunus ^{[3
]}

机构：

[1] Uludag Univ, Fac Arts & Sci, Dept Chem, TR-16059 Bursa, Turkey

[2] Uludag Univ, Fac Arts & Sci, Dept Biol, TR-16059 Bursa, Turkey

[3] Gebze Inst Technol, Dept Chem, Fac Sci, TR-41400 Kocaeli, Turkey

来源：

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY | 2015年 / 136卷

关键词：

Copper(II); 4,7-Dimethyl-1,10-phenanthroline; L-tyrosine; Single crystal X-ray diffraction; DNA binding and cleavage; Cytotoxicity; MIXED-LIGAND COMPLEXES; CRYSTAL-STRUCTURE; WEAK-INTERACTIONS; RUTHENIUM(II) COMPLEXES; BINDING PROPERTIES; CLEAVAGE; PHOTOCLEAVAGE; 1,10-PHENANTHROLINE; FLUORESCENCE; STABILITIES;

D O I：

10.1016/j.saa.2014.09.093

中图分类号：

O433 [光谱学];

学科分类号：

0703 ; 070302 ;

摘要：

Two new water-soluble copper(II) complexes, [Cu(dmphen)(2)(NO3)]NO3 (1), [Cu(dmphen)(tyr)(H2O)] NO3 center dot H2O (2) and the diquartemary salt of dmphen (dmphen = 4,7-dimethyl-1,10-phenanthroline and tyr = L-tyrosine), have been synthesized and characterized by elemental analysis, H-1 NMR, C-13 NMR and IR spectroscopy, thermal analysis and single crystal X-ray diffraction techniques. The CT-DNA binding properties of these compounds have been investigated by absorption, emission spectroscopy and thermal denaturation measurements. The supercoiled pBR322 plasmid DNA cleavage activity of these compounds has been explored by agarose gel electrophoresis. The cytotoxicity of these compounds against MCF-7, Caco-2, A549 cancer cells and BEAS-2B healthy cells was also studied by the XTT method. Complexes 1 and 2 exhibit significant cytotoxicity, with lower IC50 values than those of cisplatin. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：761 / 770

页数：10

共 32 条

[31] Synthesis, Characterization, DNA-Binding, and DNA-Photocleavage Properties of [Co(bpy)2(7-NO2-dppz)]3+, [Co(dmb)2(7-NO2-dppz)]3+, and [Co(phen)2(7-NO2-dppz)]3+Complexes: (7-Nitro-dppz=7-Nitro dipyrido[3,2-a:2'-3'-c]phenazine; bpy=2,2'-bipyridine; dmb=4,4'-dimethyl-2,2'-bipyridine; phen=1,10-phenanthroline) and their Toxicity on Different Microorganisms
Reddy, Kotha Laxma
Reddy, Y. Harish Kumar
Kumar, K. Ashwini
Vidhisha, S.
Satyanarayana, S.
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 2009, 28 (03): : 204 - 219
[32] Synthesis and Characterization of Some Nickel(II) and Copper(II) Complexes of 2-substituted-4,4,4-trifluoro1-(2-thienyl)butane-1,3-dione (TTAH), their 2,2′-Bipyridine and 1,10-Phenanthroline Adducts and X-Ray Structure of (2,2′-Bipyridine)Bis(4,4,4-trifluoro-1-(2-thienyl)butane-1,3-dionato)Nickel(II)
Woods, J. A. O.
Omoregie, H. Oluwatola
Retta, N.
Capitelli, F.
Da Silva, Ivan
SYNTHESIS AND REACTIVITY IN INORGANIC METAL-ORGANIC AND NANO-METAL CHEMISTRY, 2009, 39 (10) : 704 - 717

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