Transplants in Myelodysplastic Syndromes

被引：1

作者：

Wetzko, Katrin ^{[1
]}

Platzbecker, Uwe ^{[1
]}

机构：

[1] TUD, Univ Hosp Carl Gustav Carus, Med Clin 1, D-01307 Dresden, Germany

来源：

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 2014年 / 28卷 / 06期

关键词：

MDS; Allogeneic HSCT; Relapse; Conditioning; Azacitidine; STEM-CELL TRANSPLANTATION; ACUTE MYELOID-LEUKEMIA; ACUTE MYELOGENOUS LEUKEMIA; BONE-MARROW-TRANSPLANTATION; IDENTICAL SIBLING DONORS; VERSUS-HOST-DISEASE; SCORING SYSTEM; ALLOGENEIC TRANSPLANTATION; INDUCTION CHEMOTHERAPY; RISK MYELODYSPLASIA;

D O I：

10.1016/j.hoc.2014.08.012

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Myelodysplastic syndromes are one of the most common hematological disorders in the elderly. Therefore, an increase in the prevalence of de novo but also of secondary forms after prior chemotherapy or radiotherapy, respectively, is anticipated within the next years. Allogeneic stem cell transplantation is considered the only potentially curable therapy, but many patients are not eligible because of age or comorbidities. Reduced-intensity conditioning regimens have improved early tolerability of the procedure, although late effects remain a challenge in the care of these patients. However, hypomethylating agents have become available as alternative therapeutic approaches with a moderate toxicity profile.

引用

页码：1011 / +

页数：13

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