Transplants in Myelodysplastic Syndromes

被引：1

作者：

Wetzko, Katrin ^{[1
]}

Platzbecker, Uwe ^{[1
]}

机构：

[1] TUD, Univ Hosp Carl Gustav Carus, Med Clin 1, D-01307 Dresden, Germany

来源：

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 2014年 / 28卷 / 06期

关键词：

MDS; Allogeneic HSCT; Relapse; Conditioning; Azacitidine; STEM-CELL TRANSPLANTATION; ACUTE MYELOID-LEUKEMIA; ACUTE MYELOGENOUS LEUKEMIA; BONE-MARROW-TRANSPLANTATION; IDENTICAL SIBLING DONORS; VERSUS-HOST-DISEASE; SCORING SYSTEM; ALLOGENEIC TRANSPLANTATION; INDUCTION CHEMOTHERAPY; RISK MYELODYSPLASIA;

D O I：

10.1016/j.hoc.2014.08.012

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Myelodysplastic syndromes are one of the most common hematological disorders in the elderly. Therefore, an increase in the prevalence of de novo but also of secondary forms after prior chemotherapy or radiotherapy, respectively, is anticipated within the next years. Allogeneic stem cell transplantation is considered the only potentially curable therapy, but many patients are not eligible because of age or comorbidities. Reduced-intensity conditioning regimens have improved early tolerability of the procedure, although late effects remain a challenge in the care of these patients. However, hypomethylating agents have become available as alternative therapeutic approaches with a moderate toxicity profile.

引用

页码：1011 / +

页数：13

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[1] WHO classification and WPSS predict posttransplantation outcome in patients with myelodysplastic syndrome:: a study from the Gruppo Italiano Trapianto di Midollo Osseo (GITMO) [J].

Alessandrino, Emilio Paolo ;

Della Porta, Matteo Giovanni ;

Bacigalupo, Andrea ;

Van Lint, Maria Teresa ;

Falda, Michele ;

Onida, Francesco ;

Bernardi, Massimo ;

Iori, Anna Paola ;

Rambaldi, Alessandro ;

Cerretti, Raffaella ;

Marenco, Paola ;

Pioltelli, Pietro ;

Malcovati, Luca ;

Pascutto, Cristiana ;

Oneto, Rosi ;

Fanin, Renato ;

Bosi, Alberto ;

Levis, A. ;

Rambaldi, A. ;

Bandini, G. ;

Casini, M. ;

Rossi, G. ;

Angelucci, E. ;

Baronciani, D. ;

La Nasa, G. ;

Milone, G. ;

Mordini, N. ;

Guidi, S. ;

Bosi, A. ;

Bacigalupo, A. ;

Van Lint, M. T. ;

Corradini, P. ;

Milani, R. ;

Morra, E. ;

Marenco, P. ;

Deliliers, G. Lambretenghi ;

Onida, F. ;

Ciceri, F. ;

Bernardi, M. ;

Castagna, L. ;

Narni, F. ;

Pioltelli, P. ;

Selleri, Carmine ;

Scime, R. ;

Iannitto, E. ;

Musso, M. ;

Alessandrino, E. P. ;

Locatelli, F. ;

Martelli, F. ;

Visani, G. .

BLOOD, 2008, 112 (03) :895-902

[2] Optimal timing of allogeneic hematopoietic stem cell transplantation in patients with myelodysplastic syndrome [J].

Alessandrino, Emilio Paolo ;

Della Porta, Matteo G. ;

Malcovati, Luca ;

Jackson, Christopher H. ;

Pascutto, Cristiana ;

Bacigalupo, Andrea ;

van Lint, Maria Teresa ;

Falda, Michele ;

Bernardi, Massimo ;

Onida, Francesco ;

Guidi, Stefano ;

Iori, Anna Paola ;

Cerretti, Raffaella ;

Marenco, Paola ;

Pioltelli, Pietro ;

Angelucci, Emanuele ;

Oneto, Rosi ;

Ripamonti, Francesco ;

Rambaldi, Alessandro ;

Bosi, Alberto ;

Cazzola, Mario ;

Levis, A. ;

Rambaldi, A. ;

Bandini, G. ;

Casini, M. ;

Rossi, G. ;

Angelucci, E. ;

Baronciani, D. ;

La Nasa, G. ;

Milone, G. ;

Mordini, N. ;

Guidi, S. ;

Bosi, A. ;

Bacigalupo, A. ;

Van Lint, M. T. ;

Corradini, P. ;

Milani, R. ;

Morra, E. ;

Marenco, P. ;

Deliliers, G. Lambertenghi ;

Onida, F. ;

Ciceri, F. ;

Bernardi, M. ;

Castagna, L. ;

Narni, F. ;

Pioltelli, P. ;

Selleri, Carmine ;

Scime, R. ;

Iannitto, E. ;

Musso, M. .

AMERICAN JOURNAL OF HEMATOLOGY, 2013, 88 (07) :581-588

[3] Who is the better donor for older hematopoietic transplant recipients: an older-aged sibling or a young, matched unrelated volunteer? [J].

Alousi, Amin M. ;

Le-Rademacher, Jennifer ;

Saliba, Rima M. ;

Appelbaum, Frederick R. ;

Artz, Andrew ;

Benjamin, Jonathan ;

Devine, Steven M. ;

Kan, Fangyu ;

Laughlin, Mary J. ;

Lazarus, Hillard M. ;

Liesveld, Jane ;

Perales, Miguel-Angel ;

Maziarz, Richard T. ;

Sabloff, Mitchell ;

Waller, Edmund K. ;

Eapen, Mary ;

Champlin, Richard E. .

BLOOD, 2013, 121 (13) :2567-2573

[4] Peripheral-Blood versus Bone Marrow Stem Cells [J].

van Besien, Koen ;

Shore, Tsiporah ;

Cushing, Melissa .

NEW ENGLAND JOURNAL OF MEDICINE, 2013, 368 (03) :287-288

[5] Peripheral-Blood Stem Cells versus Bone Marrow from Unrelated Donors [J].

Anasetti, Claudio ;

Logan, Brent R. ;

Lee, Stephanie J. ;

Waller, Edmund K. ;

Weisdorf, Daniel J. ;

Wingard, John R. ;

Cutler, Corey S. ;

Westervelt, Peter ;

Woolfrey, Ann ;

Couban, Stephen ;

Ehninger, Gerhard ;

Johnston, Laura ;

Maziarz, Richard T. ;

Pulsipher, Michael A. ;

Porter, David L. ;

Mineishi, Shin ;

McCarty, John M. ;

Khan, Shakila P. ;

Anderlini, Paolo ;

Bensinger, William I. ;

Leitman, Susan F. ;

Rowley, Scott D. ;

Bredeson, Christopher ;

Carter, Shelly L. ;

Horowitz, Mary M. ;

Confer, Dennis L. .

NEW ENGLAND JOURNAL OF MEDICINE, 2012, 367 (16) :1487-1496

[6] Prognostic impact of elevated pretransplantation serum ferritin in patients undergoing myeloablative stem cell transplantation [J].

Armand, Philippe ;

Kim, Haesook T. ;

Cutler, Corey S. ;

Ho, Vincent T. ;

Koreth, John ;

Alyea, Edwin P. ;

Soiffer, Robert J. ;

Antin, Joseph H. .

BLOOD, 2007, 109 (10) :4586-4588

[7] Does iron overload really matter in stem cell transplantation? [J].

Armand, Philippe ;

Sainvil, Marie-Michele ;

Kim, Haesook T. ;

Rhodes, Joanna ;

Cutler, Corey ;

Ho, Vincent T. ;

Koreth, John ;

Alyea, Edwin P. ;

Neufeld, Ellis J. ;

Kwong, Raymond Y. ;

Soiffer, Robert J. ;

Antin, Joseph H. .

AMERICAN JOURNAL OF HEMATOLOGY, 2012, 87 (06) :569-572

[8] Comparison of Allogeneic Stem Cell Transplantation and Non-Transplant Approaches in Elderly Patients with Advanced Myelodysplastic Syndrome: Optimal Statistical Approaches and a Critical Appraisal of Clinical Results Using Non-Randomized Data [J].

Brand, Ronald ;

Putter, Hein ;

van Biezen, Anja ;

Niederwieser, Dietger ;

Martino, Rodrigo ;

Mufti, Ghulam ;

Onida, Francesco ;

Symeonidis, Argiris ;

Schmid, Christoph ;

Garderet, Laurent ;

Robin, Marie ;

van Gelder, Michel ;

Finke, Juergen ;

Bornhaeuser, Martin ;

Kobbe, Guido ;

Germing, Ulrich ;

de Witte, Theo ;

Kroeger, Nicolaus .

PLOS ONE, 2013, 8 (10)

[9] Busulfan Dose Intensity and Outcomes in Reduced-Intensity Allogeneic Peripheral Blood Stem Cell Transplantation for Myelodysplastic Syndrome or Acute Myeloid Leukemia [J].

Chen, Yi-Bin ;

Coughlin, Erin ;

Kennedy, Kevin F. ;

Alyea, Edwin P. ;

Armand, Philippe ;

Attar, Eyal C. ;

Ballen, Karen K. ;

Cutler, Corey ;

Dey, Bimalangshu R. ;

Koreth, John ;

McAfee, Steven L. ;

Spitzer, Thomas R. ;

Antin, Joseph H. ;

Soiffer, Robert J. ;

Ho, Vincent T. .

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2013, 19 (06) :981-987

[10] A decision analysis of allogeneic bone marrow transplantation for the myelodysplastic syndromes:: delayed transplantation for low-risk myelodysplasia is associated with improved outcome [J].

Cutler, CS ;

Lee, SJ ;

Greenberg, P ;

Deeg, HJ ;

Pérez, WS ;

Anasetti, C ;

Bolwell, BJ ;

Cairo, MS ;

Gale, RP ;

Klein, JP ;

Lazarus, HM ;

Liesveld, JL ;

McCarthy, PL ;

Milone, GA ;

Rizzo, JD ;

Schultz, KR ;

Trigg, ME ;

Keating, A ;

Weisdorf, DJ ;

Antin, JH ;

Horowitz, MM .

BLOOD, 2004, 104 (02) :579-585

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