Study on surfactant coating of polymeric nanoparticles for controlled delivery of anticancer drug

被引:45
作者
Mu, L
Seow, PH
Ang, SN
Feng, SS
机构
[1] Nanyang Technol Univ, Singapore MIT Alliance, Singapore 639798, Singapore
[2] Natl Univ Singapore, Dept Chem Engn, Singapore 119260, Singapore
[3] Natl Univ Singapore, Div Bioengn, Singapore 117576, Singapore
关键词
biodegradable polymer; surfactant stabiliser; emulsifier; paclitaxel; taxol; oral drug delivery; new delivery route; microencapsulation;
D O I
10.1007/s00396-004-1090-7
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
Biodegradable nanoparticles loaded with anticancer drug paclitaxel and appropriately coated with polyvinyl alcohol (PVA), polyethylene glycol (PEG) as well as D-alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS) were produced and characterised by various analysis techniques such as laser light scattering (LLS) for particle size and size distribution, scanning electron microscopy (SEM) and atomic force microscopy (AFM) for particle morphology, X-ray photoelectron spectroscopy (XPS) and Fourier Transform Infrared-Photoacoustic Spectroscopy (FTIR-PAS) for surface chemistry, and high performance liquid chromatography (HPLC) for drug encapsulation efficiency (EE) and in vitro release kinetics. The emphasis was given to the possible effects of surface coating on the physicochemical and pharmaceutical properties of paclitaxel loaded nanoparticles. It was found that the type and amount of the surfactant could significantly affect the drug EE in the nanoparticles, the particles characteristics and their in vitro release behaviour. The surfactants dominated on the nanoparticles' surface and the coated nanoparticles displayed in spherical shape with relative smooth surface within the resolution scope of the equipment. The particle size and size distribution showed close relation to the surface coating, which may also be responsible for the drug encapsulation efficiency and the in vitro release kinetics. A favourable formulation of drug loaded nanoparticles of desired properties could be obtained by optimising the fabrication parameters.
引用
收藏
页码:58 / 65
页数:8
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