Podocytes: the Weakest Link in Diabetic Kidney Disease?

被引：159

作者：

Lin, Jamie S. ^{[1
]}

Susztak, Katalin ^{[1
]}

机构：

[1] Univ Penn, Perelman Sch Med, Dept Med, Renal Electrolyte & Hypertens Div, Philadelphia, PA 19104 USA

来源：

CURRENT DIABETES REPORTS | 2016年 / 16卷 / 05期

关键词：

Diabetes; Podocytes; Albuminuria; Notch; Glomerulosclerosis; PARIETAL EPITHELIAL-CELLS; ENDOTHELIAL GROWTH-FACTOR; TGF-BETA; NEPHRIN PHOSPHORYLATION; MOUSE PODOCYTES; RENAL LESIONS; HIGH GLUCOSE; IV COLLAGEN; NEPHROPATHY; EXPRESSION;

D O I：

10.1007/s11892-016-0735-5

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Diabetes is increasing in prevalence and is the leading cause of end-stage renal disease in the United States. Diabetic kidney disease is considered a proteinuric glomerular disease. Although the glomerulus is composed of various cell types, research suggests that podocytes are critical to overall glomerular health. Podocyte injury has been identified as a pivotal event resulting in proteinuric kidney disease, glomerulosclerosis, and loss of renal function. Thus, understanding the signaling mechanisms that trigger podocyte injury in diabetic kidney disease might allow for the development of targeted therapeutics to prevent or ameliorate progression to end-stage renal failure. This review focuses on the role of podocytes in diabetic kidney disease.

引用

页数：9

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