NMDA channel blockers:: memantine and amino-aklylcyclohexanes -: In vivo characterization

被引：30

作者：

Danysz, W ^{[1
]}

Parsons, CG ^{[1
]}

Quack, G ^{[1
]}

机构：

[1] Merz & Co, Dept Pharmacol Res, D-60318 Frankfurt, Germany

来源：

AMINO ACIDS | 2000年 / 19卷 / 01期

关键词：

amino acids; NMDA; channel blockers; memantine;

D O I：

10.1007/s007260070045

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The previous overviews provided the basis for better therapeutic efficacy/tolerability of low to moderate affinity NMDA channel blockers. This prediction finds support in in vitro studies comparing protective and plasticity impairing effects (therapeutic vs. side-effect) of memantine and (+)MK-801. In fact it turned out that memantine had a far better therapeutic index. But can it be confirmed in the in vivo situation?

引用

页码：167 / 172

页数：6

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