NMDA channel blockers:: memantine and amino-aklylcyclohexanes -: In vivo characterization

被引：30

作者：

Danysz, W ^{[1
]}

Parsons, CG ^{[1
]}

Quack, G ^{[1
]}

机构：

[1] Merz & Co, Dept Pharmacol Res, D-60318 Frankfurt, Germany

来源：

AMINO ACIDS | 2000年 / 19卷 / 01期

关键词：

amino acids; NMDA; channel blockers; memantine;

D O I：

10.1007/s007260070045

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The previous overviews provided the basis for better therapeutic efficacy/tolerability of low to moderate affinity NMDA channel blockers. This prediction finds support in in vitro studies comparing protective and plasticity impairing effects (therapeutic vs. side-effect) of memantine and (+)MK-801. In fact it turned out that memantine had a far better therapeutic index. But can it be confirmed in the in vivo situation?

引用

页码：167 / 172

页数：6

共 26 条

[1]

BERMAN RM, 2000, IN PRESS BIOL PSYCHI

[2] Effects of N-methyl-D-aspartate receptor antagonists on reinforced and nonreinforced responding for ethanol in rats [J].

Bienkowski, P ;

Koros, E ;

Kostowski, W ;

Danysz, W .

ALCOHOL, 1999, 18 (2-3) :131-137

[3]

BISAGA A, 1998, ACNP 37 ANN M 14 18

[4] Neuroprotective concentrations of the N-methyl-D-aspartate open-channel blocker memantine are effective without cytoplasmic vacuolation following post-ischemic administration and do not block maze learning or long-term potentiation [J].

Chen, HSV ;

Wang, YF ;

Rayudu, PV ;

Edgecomb, P ;

Neill, JC ;

Segal, MM ;

Lipton, SA ;

Jensen, FE .

NEUROSCIENCE, 1998, 86 (04) :1121-1132

[5] ARE NMDA ANTAGONISTIC PROPERTIES RELEVANT FOR ANTIPARKINSONIAN-LIKE ACTIVITY IN RATS - CASE OF AMANTADINE AND MEMANTINE [J].

DANYSZ, W ;

GOSSEL, M ;

ZAJACZKOWSKI, W ;

DILL, D ;

QUACK, G .

JOURNAL OF NEURAL TRANSMISSION-PARKINSONS DISEASE AND DEMENTIA SECTION, 1994, 7 (03) :155-166

[6] THE EFFECTS OF THE CLINICALLY TESTED NMDA RECEPTOR ANTAGONIST MEMANTINE ON CARRAGEENAN-INDUCED THERMAL HYPERALGESIA IN RATS [J].

EISENBERG, E ;

LACROSS, S ;

STRASSMAN, AM .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1994, 255 (1-3) :123-129

[7] Ethanol and neurotransmitter interactions - From molecular to integrative effects [J].

Faingold, CL ;

N'Gouemo, P ;

Riaz, A .

PROGRESS IN NEUROBIOLOGY, 1998, 55 (05) :509-535

[8]

HERMAN BH, 1995, NEUROPSYCHOPHARMACOL, V13, P269, DOI 10.1016/0893-133X(95)00140-9

[9] Brain penetration and in vivo recovery of NMDA receptor antagonists amantadine and memantine: A quantitative microdialysis study [J].

Hesselink, MB ;

De Boer, BG ;

Breimer, DD ;

Danysz, W .

PHARMACEUTICAL RESEARCH, 1999, 16 (05) :637-642

[10] Evidence for alcohol anti-craving properties of memantine [J].

Holter, SM ;

Danysz, W ;

Spanagel, R .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1996, 314 (03) :R1-R2

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