The transcription machinery in mammalian mitochondria

被引：85

作者：

Gaspari, M

Larsson, NG

Gustafsson, CM ^{[1
]}

机构：

[1] Karolinska Inst, Dept Med Nutr, Novum, SE-14186 Stockholm, Sweden

[2] Karolinska Inst, Dept Biosci, Novum, SE-14186 Stockholm, Sweden

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS | 2004年 / 1659卷 / 2-3期

关键词：

POLRMT; TFAM; TFB2M; mitochondrion; transcription;

D O I：

10.1016/j.bbabio.2004.10.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Initiation of transcription at mitochondrial promoters in mammalian cells requires the simultaneous presence of a monomeric mitochondrial RNA polymerase, mitochondrial transcription factor A, and either transcription factor B1 or B2. We here review recent progress in our understanding of how these basal factors cooperate in the initiation and regulation of mitochondrial transcription. We describe the evolutionary origin of individual transcription factors and discuss how these phylogenetic relationships may facilitate a molecular understanding of the mitochondrial transcription machinery. (C) 2004 Elsevier B.V. All rights reserved.

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收藏

页码：148 / 152

页数：5

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