Repeated administration of high dose levodopa enhances hydroxyl radical production in the rat striatum denervated with 6-hydroxydopamine

被引:15
作者
Ishida, Y [1 ]
Hashiguchi, H [1 ]
Todaka, K [1 ]
Ishizuka, Y [1 ]
Mitsuyama, Y [1 ]
机构
[1] Miyazaki Med Coll, Dept Psychiat, Miyazaki 8891692, Japan
关键词
salicylate trapping; 2,3-dihydroxybenzoic acid; hydroxyl radical; levodopa; microdialysis; striatum; 6-hydroxydopamine;
D O I
10.1016/S0304-3940(00)01320-3
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
We examined whether levodopa (L-DOPA) might increase production of hydroxyl radicals in intact and dopamine-denervated rat striatum. Salicylate trapping combined with in vivo microdialysis provided measurements of 2,3-dihydroxybenzoic acid (2,3-DHBA) as a marker of hydroxyl radical production. Acute administration of high-dose L-DOPA (200, 500 mg/kg, i.p.) did not alter 2,3-DHBA levels in intact striatum or in striatum denervated with 6-hydroxydopamine. On the other hand, L-DOPA administration (200 mg/kg, i.p.) transiently increased 2,3-DHBA in dopamine-denervated striatum of rats after repeated administration of L-DOPA (200 mg/kg, i.p., once daily for 76 days). The results indicated that repeated administration of high dose L-DOPA increased production of hydroxyl radicals in dopamine-denervated striatum. (C) 2000 Published by Elsevier Science Ireland Ltd.
引用
收藏
页码:33 / 36
页数:4
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