The "π-Clamp" Offers a New Strategy for Site-Selective Protein Modification

被引：5

作者：

Tharp, Jeffery M. ^{[1
]}

Liu, Wenshe R. ^{[1
]}

机构：

[1] Texas A&M Univ, Dept Chem, College Stn, TX 77843 USA

来源：

CHEMBIOCHEM | 2016年 / 17卷 / 10期

基金：

美国国家科学基金会;

关键词：

cysteine; pi clamp; protein modification; site selectivity; CYSTEINE; CHEMISTRY; ANTIBODY;

D O I：

10.1002/cbic.201600106

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pentelute and co-workers have identified a small encodable cysteine-containing peptide sequence that allows selective modification with perfluoroaryl probes. This π-clamp requires no external catalyst and is not limited to certain positions within a protein. © 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：883 / 885

页数：3

共 50 条

[31] Site-selective protein modification via disulfide rebridging for fast tetrazine/trans-cyclooctene bioconjugation [J].

Xu, Lujuan ;

Raabe, Marco ;

Zegota, Maksymilian M. M. ;

Nogueira, Joao C. F. ;

Chudasama, Vijay ;

Kuan, Seah Ling ;

Weil, Tanja .

ORGANIC & BIOMOLECULAR CHEMISTRY, 2020, 18 (06) :1140-1147

[32] Transition metal catalyzed site-selective cysteine diversification of proteins [J].

Jbara, Muhammad .

PURE AND APPLIED CHEMISTRY, 2021, 93 (02) :169-186

[33] Total Synthesis of Cercidinin A via a Sequential Site-selective Acylation Strategy [J].

Shibayama, Hiromitsu ;

Ueda, Yoshihiro ;

Kawabata, Takeo .

CHEMISTRY LETTERS, 2020, 49 (02) :182-185

[34] Chemoselective and Site-Selective Lysine-Directed Lysine Modification Enables Single-Site Labeling of Native Proteins [J].

Adusumalli, Srinivasa Rao ;

Rawale, Dattatraya Gautam ;

Thakur, Kalyani ;

Purushottam, Landa ;

Reddy, Neelesh C. ;

Kalra, Neetu ;

Shukla, Sanjeev ;

Rai, Vishal .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2020, 59 (26) :10332-10336

[35] Tyrosine-Triazolinedione Bioconjugation as Site-Selective Protein Modification Starting from RAFT-Derived Polymers [J].

Vandewalle, Stef ;

De Coen, Ruben ;

De Geest, Bruno G. ;

Du Prez, Filip E. .

ACS MACRO LETTERS, 2017, 6 (12) :1368-1372

[36] Palladium-mediated site-selective Suzuki-Miyaura protein modification at genetically encoded aryl halides [J].

Spicer, Christopher D. ;

Davis, Benjamin G. .

CHEMICAL COMMUNICATIONS, 2011, 47 (06) :1698-1700

[37] Site-selective chemical cleavage of peptide bonds [J].

Elashal, Hader E. ;

Raj, Monika .

CHEMICAL COMMUNICATIONS, 2016, 52 (37) :6304-6307

[38] Cleavable Cys labeling directed Lys site-selective stapling and single-site modification [J].

Li, Jian ;

Hu, Qi-Long ;

Song, Zhendong ;

Chan, Albert S. C. ;

Xiong, Xiao-Feng .

SCIENCE CHINA-CHEMISTRY, 2022, 65 (07) :1356-1361

[39] Cleavable Cys labeling directed Lys site-selective stapling and single-site modification [J].

Jian Li ;

Qi-Long Hu ;

Zhendong Song ;

Albert S. C. Chan ;

Xiao-Feng Xiong .

Science China Chemistry, 2022, 65 :1356-1361

[40] Construction of homogeneous antibody-drug conjugates using site-selective protein chemistry [J].

Akkapeddi, Padma ;

Azizi, Saara-Anne ;

Freedy, Allyson M. ;

Cal, Pedro M. S. D. ;

Gois, Pedro M. P. ;

Bernardes, Goncalo J. L. .

CHEMICAL SCIENCE, 2016, 7 (05) :2954-2963

← 1 2 3 4 5 →