The "π-Clamp" Offers a New Strategy for Site-Selective Protein Modification

被引：5

作者：

Tharp, Jeffery M. ^{[1
]}

Liu, Wenshe R. ^{[1
]}

机构：

[1] Texas A&M Univ, Dept Chem, College Stn, TX 77843 USA

来源：

CHEMBIOCHEM | 2016年 / 17卷 / 10期

基金：

美国国家科学基金会;

关键词：

cysteine; pi clamp; protein modification; site selectivity; CYSTEINE; CHEMISTRY; ANTIBODY;

D O I：

10.1002/cbic.201600106

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pentelute and co-workers have identified a small encodable cysteine-containing peptide sequence that allows selective modification with perfluoroaryl probes. This π-clamp requires no external catalyst and is not limited to certain positions within a protein. © 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：883 / 885

页数：3

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