Current Prognostic and Predictive Biomarkers for Endometrial Cancer in Clinical Practice: Recommendations/Proposal from the Italian Study Group

被引：17

作者：

Zannoni, Gian Franco ^{[1
,2
]}

Bragantini, Emma ^{[3
]}

Castiglione, Francesca ^{[4
]}

Fassan, Matteo ^{[5
]}

Troncone, Giancarlo ^{[6
]}

Inzani, Frediano ^{[1
]}

Pesci, Anna ^{[7
]}

Santoro, Angela ^{[1
]}

Fraggetta, Filippo ^{[8
,9
]}

机构：

[1] Fdn Policlin Univ A Gemelli Ist Ric & Cura Caratt, Unita Ginecopatol & Patol Mammaria, Dipartimento Sci Salute Donna Bambino & Sanita Pu, Rome, Italy

[2] Univ Cattolica Sacro Cuore, Ist Anat Patol, Rome, Italy

[3] Osped S Chiara, Dept Surg Pathol, Trento, Italy

[4] Careggi Univ Hosp, Histopathol & Mol Diagnost, Florence, Italy

[5] Univ Padua, Dept Med DIMED, Padua, Italy

[6] Univ Naples Federico II, Dept Publ Hlth, Naples, Italy

[7] Sacred Heart Hosp Don Calabria Negrar, Dept Pathol, Verona, Italy

[8] Cannizzaro Hosp, Pathol Unit, Catania, Italy

[9] Gravina Hosp, Pathol Unit, Caltagirone, Italy

来源：

FRONTIERS IN ONCOLOGY | 2022年 / 12卷

关键词：

endometrial cancer; prognostic markers; histomolecular classification; pathological guidelines; prognostic stratification; MISMATCH REPAIR DEFICIENCY; ESTROGEN-RECEPTOR-ALPHA; CLEAR-CELL CARCINOMA; PROGESTERONE-RECEPTOR; LYNCH-SYNDROME; MICROSATELLITE INSTABILITY; ADHESION MOLECULE; COLORECTAL-CANCER; DOMAIN MUTATIONS; PD-L1; EXPRESSION;

D O I：

10.3389/fonc.2022.805613

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Endometrial carcinoma (EC) is the most common gynecological malignant disease in high-income countries, such as European countries and the USA. The 2020 edition of the World Health Organization (WHO) Classification of Tumors of the Female Genital Tract underlines the important clinical implications of the proposed new histomolecular classification system for ECs. In view of the substantial genetic and morphological heterogeneity in ECs, both classical pthological parameters and molecular classifiers have to be integrated in the pathology report. This review will focus on the most commonly adopted immunohistochemical and molecular biomarkers in daily clinical characterization of EC, referring to the most recent published recommendations, guidelines, and expert opinions.

引用

页数：20

共 154 条

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