Understanding Frailty in Cancer Patients

被引：40

作者：

Baijal, Pooja ^{[1
]}

Periyakoil, Vyjeyanthi ^{[1
]}

机构：

[1] Stanford Hosp & Clin, Palo Alto, CA 94305 USA

来源：

CANCER JOURNAL | 2014年 / 20卷 / 05期

关键词：

Frailty; older adults; cancer; geriatric assessment; COMPREHENSIVE GERIATRIC ASSESSMENT; QUALITY-OF-LIFE; BREAST-CANCER; ELDERLY-PATIENTS; SOCIAL SUPPORT; OLDER PATIENTS; NUTRITIONAL-STATUS; PREDICT MORTALITY; PROSTATE-CANCER; PREVALENCE;

D O I：

10.1097/PPO.0000000000000068

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

As population ages, the number of older adults with cancer is increasing rapidly. Chronological age per se is a poor guide for an oncologist to determine tolerance to cancer treatment. Older adults have been underrepresented in cancer clinical trials, leading to paucity of guidelines to meet the treatment challenges in this population. To evaluate an older adult with cancer, oncologists must understand age-related changes and identify the subset of population who is vulnerable and at risk of cancer treatment toxicity. Comprehensive geriatric assessments focusing on functional status, multimorbidity, nutritional status, cognitive impairment, and psychosocial support help recognize heterogeneity among older adults, leading to individualized approaches toward cancer treatment. The treatment decisions need to be made in collaboration with the patient's values and preferences.

引用

收藏

页码：358 / 366

页数：9

相关论文

共 75 条

[11] Older Breast Cancer Survivors: Geriatric Assessment Domains Are Associated With Poor Tolerance of Treatment Adverse Effects and Predict Mortality Over 7 Years of Follow-Up [J].

Clough-Gorr, Kerri M. ;

Stuck, Andreas E. ;

Thwin, Soe Soe ;

Silliman, Rebecca A. .

JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (03) :380-386

[12] Background for the proposal of SIOG guidelines for the management of prostate cancer in senior adults [J].

Droz, Jean-Pierre ;

Balducci, Lodovico ;

Bolla, Michel ;

Emberton, Mark ;

Fitzpatrick, John M. ;

Joniau, Steven ;

Kattan, Michael W. ;

Monfardini, Silvio ;

Moul, Judd W. ;

Naeim, Arash ;

van Poppel, Hendrik ;

Saad, Fred ;

Sternberg, Cora N. .

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 2010, 73 (01) :68-91

[13] Comparison of 2 frailty indexes for prediction of falls, disability, fractures, and death in older women [J].

Ensrud, Kristine E. ;

Ewing, Susan K. ;

Taylor, Brent C. ;

Fink, Howard A. ;

Cawthon, Peggy M. ;

Stone, Katie L. ;

Hillier, Teresa A. ;

Cauley, Jane A. ;

Hochberg, Marc C. ;

Rodondi, Nicolas ;

Tracy, J. Kathleen ;

Cummings, Steven R. .

ARCHIVES OF INTERNAL MEDICINE, 2008, 168 (04) :382-389

[14] Use of comprehensive geriatric assessment in older cancer patients: Recommendations from the task force on CGA of the International Society of Geriatric Oncology (SIOG) [J].

Extermann, M ;

Aapro, M ;

Bernabei, RB ;

Cohen, HJ ;

Droz, JP ;

Lichtman, S ;

Mor, V ;

Monfardini, S ;

Repetto, L ;

Sorbye, L ;

Topinkova, E .

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 2005, 55 (03) :241-252

[15] A comprehensive geriatric intervention detects multiple problems in older breast cancer patients [J].

Extermann, M ;

Meyer, J ;

McGinnis, M ;

Crocker, TT ;

Corcoran, MB ;

Yoder, J ;

Haley, WE ;

Chen, HB ;

Boulware, D ;

Balducci, L .

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 2004, 49 (01) :69-75

[16] The Biology of Aging and Frailty [J].

Fedarko, Neal S. .

CLINICS IN GERIATRIC MEDICINE, 2011, 27 (01) :27-+

[17] EXERCISE TRAINING AND NUTRITIONAL SUPPLEMENTATION FOR PHYSICAL FRAILTY LN VERY ELDERLY PEOPLE [J].

FIATARONE, MA ;

ONEILL, EF ;

RYAN, ND ;

CLEMENTS, KM ;

SOLARES, GR ;

NELSON, ME ;

ROBERTS, SB ;

KEHAYIAS, JJ ;

LIPSITZ, LA ;

EVANS, WJ .

NEW ENGLAND JOURNAL OF MEDICINE, 1994, 330 (25) :1769-1775

[18] Frailty in older adults: Evidence for a phenotype [J].

Fried, LP ;

Tangen, CM ;

Walston, J ;

Newman, AB ;

Hirsch, C ;

Gottdiener, J ;

Seeman, T ;

Tracy, R ;

Kop, WJ ;

Burke, G ;

McBurnie, MA .

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2001, 56 (03) :M146-M156

[19] Effect of comorbidity on short-term outcomes and cost of care after head and neck cancer surgery in the elderly [J].

Genther, Dane J. ;

Gourin, Christine G. .

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 2015, 37 (05) :685-693

[20] Transitions between frailty states among community-living older persons [J].

Gill, TM ;

Gahbauer, EA ;

Allore, HG ;

Han, L .

ARCHIVES OF INTERNAL MEDICINE, 2006, 166 (04) :418-423

← 1 2 3 4 5 6 7 8 →