Simultaneous chiral analysis of methamphetamine and related compounds by capillary electrophoresis/mass spectrometry using anionic cyclodextrin

被引:24
作者
Iio, R
Chinaka, S
Takayama, N
Hayakawa, K
机构
[1] Ishikawa Prefectural Police Headquarters, Forens Sci Lab, Kanazawa, Ishikawa 9208553, Japan
[2] Kanazawa Univ, Grad Sch Nat & Technol, Kanazawa, Ishikawa 9201192, Japan
关键词
D O I
10.2116/analsci.21.15
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
A capillary electrophoresis/mass spectrometry method for the simultaneous chiral analysis of enantiomers of methamphetamine (MA), amphetamine (AP), dimethylamphetamine (DMA), ephedrine (EP), norephedrine (NE) and methylephedrine (ME) in urine has been developed. The background electrolyte was I M formic acid (pH 1.7). Using 0.85 mM heptakis(2,6-diacethyl-6-sulfato)-beta-cyclodextrin as the chiral selector. the 12 enantiomers were completely separated within 25 min. The detection limits were 0.01 mug mL(-1) for the enantiomers of MA, AP, DMA, EP and ME, and 0.02 mug mL(-1) for the enantiomers of NE using selected ion monitoring. The reproducibilities of within-run (n = 4) for the migration times and peak areas of the standard mixture were under 0.58% and 7.83%. respectively. The calibration curves of the peak areas of the 12 enantiomers were linear in the range of 0.05 - 10 mug mL(-1). This method was applicable to the analysis of urine samples.
引用
收藏
页码:15 / 19
页数:5
相关论文
共 20 条
[1]  
Amini A, 2001, ELECTROPHORESIS, V22, P3107, DOI 10.1002/1522-2683(200109)22:15<3107::AID-ELPS3107>3.0.CO
[2]  
2-Z
[3]   Simultaneous chiral analysis of methamphetamine and related compounds by capillary electrophoresis [J].
Chinaka, S ;
Tanaka, S ;
Takayama, N ;
Komai, K ;
Ohshima, T ;
Ueda, K .
JOURNAL OF CHROMATOGRAPHY B, 2000, 749 (01) :111-118
[4]  
CHINAKA S, 2004, JPN J SCI TECHNOL ID, V9, P103
[5]  
CHINAKA S, 2003, JPN J FORENSIC TOXIC, V21, P29
[6]  
HAYAKAWA K, 1993, BIOL PHARM BULL, V16, P817
[7]   Study on the chiral recognition of the enantiomers of ephedrine derivatives with neutral and sulfated heptakis(2,3-O-diacetyl)-β-cyclodextrins using capillary electrophoresis, UV, nuclear magnetic resonance spectroscopy and mass spectrometry [J].
Hellriegel, C ;
Händel, H ;
Wedig, M ;
Steinhauer, S ;
Sörgel, F ;
Albert, K ;
Holzgrabe, U .
JOURNAL OF CHROMATOGRAPHY A, 2001, 914 (1-2) :315-324
[8]   Determination of enantiomeric amphetamines as metabolites of illicit amphetamines and selegiline in urine by capillary electrophoresis using modified β-cyclodextrin [J].
Heo, YJ ;
Whang, YS ;
In, MK ;
Lee, KJ .
JOURNAL OF CHROMATOGRAPHY B, 2000, 741 (02) :221-230
[9]   Simultaneous chiral determination of methamphetamine and its metabolites in urine by capillary electrophoresis-mass spectrometry [J].
Iio, R ;
Chinaka, S ;
Tanaka, S ;
Takayama, N ;
Hayakawa, K .
ANALYST, 2003, 128 (06) :646-650
[10]  
IIO R, 2001, JPN J SCI TECHNOL ID, V6, P21