DNA Methylation and Its Implications and Accessibility for Neuropsychiatric Therapeutics

被引：57

作者：

Day, Jeremy J. ^{[1
]}

Kennedy, Andrew J. ^{[1
]}

Sweatt, J. David ^{[1
]}

机构：

[1] Univ Alabama Birmingham, Dept Neurobiol, Birmingham, AL 35294 USA

来源：

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 55 | 2015年 / 55卷

关键词：

epigenetics; neuropharmacology; DNMT; Tet oxidase; cytosine methylation; demethylation; learning; memory; cognitive disorders; cognitive enhancement; NEURONAL-ACTIVITY; TET PROTEINS; TRANSCRIPTION FACTORS; GENE-EXPRESSION; 5-METHYLCYTOSINE; DEMETHYLATION; BINDING; MECP2; 5-HYDROXYMETHYLCYTOSINE; MECHANISMS;

D O I：

10.1146/annurev-pharmtox-010814-124527

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In this review, we discuss the potential pharmacological targeting of a set of powerful epigenetic mechanisms: DNA methylation control systems in the central nervous system (CNS). Specifically, we focus on the possible use of these targets for novel future treatments for learning and memory disorders. We first describe several unique pharmacological attributes of epigenetic mechanisms, especially DNA cytosine methylation, as potential drug targets. We then present an overview of the existing literature regarding DNA methylation control pathways and enzymes in the nervous system, particularly as related to synaptic function, plasticity, learning and memory. Lastly, we speculate upon potential categories of CNS cognitive disorders that might be amenable to methylomic targeting.

引用

页码：591 / 611

页数：21

共 120 条

[1] Epigenetic Determinants of Healthy and Diseased Brain Aging and Cognition [J].

Akbarian, Schahram ;

Beeri, Michal Schnaider ;

Haroutunian, Vahram .

JAMA NEUROLOGY, 2013, 70 (06) :711-718

[2] Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2 [J].

Amir, RE ;

Van den Veyver, IB ;

Wan, M ;

Tran, CQ ;

Francke, U ;

Zoghbi, HY .

NATURE GENETICS, 1999, 23 (02) :185-188

[3]

[Anonymous], 2014, NATURE, V506, P131

[4] In Vivo Control of CpG and Non-CpG DNA Methylation by DNA Methyltransferases [J].

Arand, Julia ;

Spieler, David ;

Karius, Tommy ;

Branco, Miguel R. ;

Meilinger, Daniela ;

Meissner, Alexander ;

Jenuwein, Thomas ;

Xu, Guoliang ;

Leonhardt, Heinrich ;

Wolf, Verena ;

Walter, Joern .

PLOS GENETICS, 2012, 8 (06)

[5] Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene [J].

Bell, AC ;

Felsenfeld, G .

NATURE, 2000, 405 (6785) :482-485

[6] RNA Targeting Therapeutics: Molecular Mechanisms of Antisense Oligonucleotides as a Therapeutic Platform [J].

Bennett, C. Frank ;

Swayze, Eric E. .

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 2010, 50 :259-293

[7] Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project [J].

Birney, Ewan ;

Stamatoyannopoulos, John A. ;

Dutta, Anindya ;

Guigo, Roderic ;

Gingeras, Thomas R. ;

Margulies, Elliott H. ;

Weng, Zhiping ;

Snyder, Michael ;

Dermitzakis, Emmanouil T. ;

Stamatoyannopoulos, John A. ;

Thurman, Robert E. ;

Kuehn, Michael S. ;

Taylor, Christopher M. ;

Neph, Shane ;

Koch, Christoph M. ;

Asthana, Saurabh ;

Malhotra, Ankit ;

Adzhubei, Ivan ;

Greenbaum, Jason A. ;

Andrews, Robert M. ;

Flicek, Paul ;

Boyle, Patrick J. ;

Cao, Hua ;

Carter, Nigel P. ;

Clelland, Gayle K. ;

Davis, Sean ;

Day, Nathan ;

Dhami, Pawandeep ;

Dillon, Shane C. ;

Dorschner, Michael O. ;

Fiegler, Heike ;

Giresi, Paul G. ;

Goldy, Jeff ;

Hawrylycz, Michael ;

Haydock, Andrew ;

Humbert, Richard ;

James, Keith D. ;

Johnson, Brett E. ;

Johnson, Ericka M. ;

Frum, Tristan T. ;

Rosenzweig, Elizabeth R. ;

Karnani, Neerja ;

Lee, Kirsten ;

Lefebvre, Gregory C. ;

Navas, Patrick A. ;

Neri, Fidencio ;

Parker, Stephen C. J. ;

Sabo, Peter J. ;

Sandstrom, Richard ;

Shafer, Anthony .

NATURE, 2007, 447 (7146) :799-816

[8] TCF4, Schizophrenia, and Pitt-Hopkins Syndrome [J].

Blake, Derek J. ;

Forrest, Marc ;

Chapman, Ria M. ;

Tinsley, Caroline L. ;

O'Donovan, Michael C. ;

Owen, Michael J. .

SCHIZOPHRENIA BULLETIN, 2010, 36 (03) :443-447

[9] Analysing and interpreting DNA methylation data [J].

Bock, Christoph .

NATURE REVIEWS GENETICS, 2012, 13 (10) :705-719

[10] Quantitative comparison of genome-wide DNA methylation mapping technologies [J].

Bock, Christoph ;

Tomazou, Eleni M. ;

Brinkman, Arie B. ;

Mueller, Fabian ;

Simmer, Femke ;

Gu, Hongcang ;

Jaeger, Natalie ;

Gnirke, Andreas ;

Stunnenberg, Hendrik G. ;

Meissner, Alexander .

NATURE BIOTECHNOLOGY, 2010, 28 (10) :1106-U196

← 1 2 3 4 5 6 7 8 9 10 →