Gold-Catalyzed Access to Isophosphinoline 2-Oxides

被引：6

作者：

Hariri, Mina ^{[1
,2
]}

Darvish, Fatemeh ^{[2
]}

Ndong, Karen-Pacelye Mengue Me ^{[1
,3
]}

Sechet, Nora ^{[1
]}

Chacktas, Geraud ^{[1
]}

Boosaliki, Hooriye ^{[1
,2
]}

Do, Minh Loan Tran ^{[1
]}

Mwande-Maguene, Gabin ^{[3
]}

Lebibi, Jacques ^{[3
]}

Burilov, Alexander R. ^{[4
]}

Ayad, Tahar ^{[1
]}

Virieux, David ^{[1
]}

Pirat, Jean-Luc ^{[1
]}

机构：

[1] Univ Montpellier, CNRS, ENSCM, ICGM, Montpellier, France

[2] KN Toosi Univ Technol, Dept Chem, POB, Tehran 158754416, Iran

[3] Univ Sci & Tech Masuku, Franceville, Gabon

[4] RAS, FRC Kazan Sci Ctr, Arbuzov Inst Organ & Phys Chem, Kazan 420088, Russia

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2021年 / 86卷 / 11期

关键词：

CYCLIZATION; PHOSPHORUS; ROUTE;

D O I：

10.1021/acs.joc.1c00648

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Gold(I)-catalyzed reactions of electron-poor alkynes are still a challenging process. A straightforward synthesis of phosphorus-based hetero-cycles, namely, 2-phenyl 1H-isophosphinoline 2-oxides 1, is reported. The reaction used PPh3AuCl precatalyst in combination with triflic acid under microwave activation and afforded isophosphinoline 2-oxides 1 in moderate to quantitative yields through a fully regioselective 6-endo-dig hydroarylation cyclization, paving the way toward an effective synthesis of phosphorus heterocycles.

引用

页码：7813 / 7824

页数：12

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