Tumor contact length of prostate cancer determined by a three-dimensional method on multiparametric magnetic resonance imaging predicts extraprostatic extension and biochemical recurrence

被引:3
作者
Miyamoto, Shunsuke [1 ]
Goto, Keisuke [1 ]
Honda, Yukiko [2 ]
Terada, Hiroaki [2 ]
Fujii, Shinsuke [1 ]
Ueno, Takeshi [1 ,5 ]
Fukuoka, Kenichiro [1 ]
Sekino, Yohei [1 ]
Kitano, Hiroyuki [1 ]
Ikeda, Kenichiro [1 ]
Hieda, Keisuke [1 ]
Inoue, Shogo [1 ]
Hayashi, Tetsutaro [1 ]
Teishima, Jun [1 ]
Takeshima, Yukio [3 ]
Yasui, Wataru [4 ]
Awai, Kazuo [2 ]
Matsubara, Akio [1 ,6 ]
机构
[1] Hiroshima Univ, Grad Sch Biomed & Hlth Sci, Dept Urol, Hiroshima, Japan
[2] Hiroshima Univ, Grad Sch Biomed & Hlth Sci, Dept Diagnost Radiol, Hiroshima, Japan
[3] Hiroshima Univ, Grad Sch Biomed & Hlth Sci, Dept Pathol, Hiroshima, Japan
[4] Hiroshima Univ, Grad Sch Biomed & Hlth Sci, Dept Mol Pathol, Hiroshima, Japan
[5] Nakatsu Daiichi Hosp, Dept Urol, Nakatsu, Japan
[6] Hiroshima Gen Hosp, Hatsukaichi, Japan
关键词
biochemical recurrence; multiparametric magnetic resonance imaging; prostate cancer; tumor contact length; INTEROBSERVER AGREEMENT; RADICAL PROSTATECTOMY; DATA SYSTEM; ACCURACY; MRI; GUIDELINES; CARCINOMA; RISK;
D O I
10.1111/iju.14633
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Objective To evaluate the clinical benefit of tumor contact length as a predictor of pathological extraprostatic extension and biochemical recurrence in patients undergoing prostatectomy. Methods A total of 91 patients who underwent 3T multiparametric magnetic resonance imaging before prostatectomy from April 2014 to July 2019 were included. A total of 94 prostate cancer foci were analyzed retrospectively. We evaluated maximum tumor contact length, which was determined to be the maximum value in the three-dimensional directions, as a predictor of pathological extraprostatic extension and biochemical recurrence. Results A total of 19 lesions (20.2%) had positive pathological extraprostatic extension. Areas under the curves showed maximum tumor contact length to be a significantly better parameter to predict pathological extraprostatic extension than the Prostate Imaging Reporting and Data System (P = 0.002), tumor maximal diameter (P = 0.001), prostate-specific antigen (P = 0.020), Gleason score (P < 0.001), and clinical T stage (P < 0.001). Multivariate analysis showed maximum tumor contact length (P = 0.003) to be an independent risk factor for predicting biochemical recurrence. We classified the patients using preoperative factors (prostate-specific antigen >10, Gleason score >3 + 4 and maximum tumor contact length >10 mm) into three groups: (i) high-risk group (patients having all factors); (ii) intermediate-risk group (patients having two of three factors); and (iii) low-risk group (patients having only one or none of the factors). Kaplan-Meier curves showed that the high-risk group had significantly worse biochemical recurrence than the intermediate-risk group (P = 0.042) and low-risk group (P < 0.001). Conclusions Our findings suggest that maximum tumor contact length is an independent predictor of pathological extraprostatic extension and biochemical recurrence. A risk stratification system using prostate-specific antigen, Gleason score and maximum tumor contact length might be useful for preoperative assessment of prostate cancer patients.
引用
收藏
页码:1012 / 1018
页数:7
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