Drinking Hydrogen Water Ameliorated Cognitive Impairment in Senescence-Accelerated Mice

被引：55

作者：

Gu, Yeunhwa ^{[2
]}

Huang, Chien-Sheng ^{[1
,3
,4
]}

Inoue, Tota ^{[2
]}

Yamashita, Takenori ^{[2
]}

Ishida, Torao ^{[2
]}

Kang, Ki-Mun ^{[5
]}

Nakao, Atsunori ^{[1
]}

机构：

[1] Univ Pittsburgh, Med Ctr, Dept Surg, Pittsburgh, PA 15213 USA

[2] Suzuka Univ Med Sci, Grad Sch Hlth Sci, Suzuka, Mie 5100293, Japan

[3] Taipei Vet Gen Hosp, Div Thorac Surg, Dept Surg, Taipei 112, Taiwan

[4] Natl Yang Ming Univ, Sch Med, Taipei 112, Taiwan

[5] Gyeongsang Natl Univ Hosp, Dept Therapeut Radiol, Gyeongsang Inst Hlth Sci, Jinju 660701, South Korea

来源：

JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION | 2010年 / 46卷 / 03期

关键词：

hydrogen water; magnesium stick; senescence; oxidative stress; cognitive disorder; THERAPEUTIC ANTIOXIDANT; MOLECULAR-HYDROGEN; ALZHEIMERS-DISEASE; MURINE MODEL; MOUSE MODEL; HIPPOCAMPUS; BRAIN; SAM; DEGENERATION; MECHANISM;

D O I：

10.3164/jcbn.10-19

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Hydrogen has been reported to have neuron protective effects due to its antioxidant properties, but the effects of hydrogen on cognitive impairment due to senescence-related brain alterations and the underlying mechanisms have not been characterized. In this study, we investigated the efficacies of drinking hydrogen water for prevention of spatial memory decline and age-related brain alterations using senescence-accelerated prone mouse 8 (SAMP8), which exhibits early aging syndromes including declining learning ability and memory. However, treatment with hydrogen water for 30 days prevented age-related declines in cognitive ability seen in SAMP8 as assessed by a water maze test and was associated with increased brain serotonin levels and elevated serum antioxidant activity. In addition, drinking hydrogen water for 18 weeks inhibited neurodegeneration in hippocampus, while marked loss of neurons was noted in control, aged brains of mice receiving regular water. On the basis of our results, hydrogen water merits further investigation for possible therapeutic/preventative use for age-related cognitive disorders.

引用

页码：269 / 276

页数：8

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