Regular exercise is beneficial to a mouse model of amyotrophic lateral sclerosis

被引：131
作者：
Kirkinezos, IG
Hernandez, D
Bradley, WG
Moraes, CT
机构：
[1] Univ Miami, Sch Med, Dept Cell Biol & Anat, Miami, FL 33136 USA
[2] Univ Miami, Sch Med, Dept Neurol, Miami, FL 33136 USA
来源：
ANNALS OF NEUROLOGY | 2003年 / 53卷 / 06期
关键词：
D O I：
10.1002/ana.10597
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
We tested whether a regular exercise regimen was associated with a change in the life span of G93A-SOD1 transgenic mice, a model of familial AILS. Regular treadmill running for 10 weeks led to a significant increase in the life span of G93A-SOD1 mice. The effect was stronger in male mice, whereas there was only a trend between exercised and sedentary female G93A-SOD1 mice. The data suggest that regular exercise has a beneficial effect on the progression of ALS.
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页码：804 / 807
页数：4
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