An international trial of antioxidants in the prevention of preeclampsia (INTAPP)

被引：98

作者：

Xu, Hairong ^{[1
]}

Perez-Cuevas, Ricardo ^{[2
]}

Xiong, Xu ^{[4
]}

Reyes, Hortensia ^{[3
]}

Roy, Chantal ^{[1
]}

Julien, Pierre ^{[5
]}

Smith, Graeme ^{[6
]}

von Dadelszen, Peter ^{[7
]}

Leduc, Line ^{[1
]}

Audibert, Francois ^{[1
]}

Moutquin, Jean-Marie ^{[8
]}

Piedboeuf, Bruno ^{[5
]}

Shatenstein, Bryna ^{[9
]}

Parra-Cabrera, Socorro ^{[3
]}

Choquette, Pierre ^{[10
]}

Winsor, Stephanie ^{[11
]}

Wood, Stephen ^{[12
]}

Benjamin, Alice ^{[13
]}

Walker, Mark ^{[14
]}

Helewa, Michael ^{[15
]}

Dube, Johanne ^{[16
]}

Tawagi, Georges ^{[14
]}

Seaward, Gareth ^{[17
]}

Ohlsson, Arne ^{[17
]}

Magee, Laura A. ^{[7
]}

Olatunbosun, Femi ^{[18
]}

Gratton, Robert ^{[19
]}

Shear, Roberta ^{[20
]}

Demianczuk, Nestor ^{[21
]}

Collet, Jean-Paul ^{[7
]}

Wei, Shuqin ^{[1
]}

Fraser, William D. ^{[1
]}

机构：

[1] Univ Montreal, Hop Ste Justine, Dept Obstet & Gynecol, Montreal, PQ H3T 1C5, Canada

[2] Inst Mexicano Seguro Sosial, Mexico City, DF, Mexico

[3] Natl Inst Publ Hlth, Cuernavaca, Morelos, Mexico

[4] Tulane Univ, New Orleans, LA 70118 USA

[5] CHUQ, Ctr Rech, Quebec City, PQ, Canada

[6] Kingston Gen Hosp, Kingston, ON K7L 2V7, Canada

[7] Childrens & Womens Hlth Ctr BC, Vancouver, BC, Canada

[8] Hop Fleurimont, CHUS, Sherbrooke, PQ, Canada

[9] Inst Univ Geriatrie, Montreal, PQ, Canada

[10] Cite Sante, Laval, PQ, Canada

[11] McMaster Med Ctr, Hamilton, ON, Canada

[12] Foothills Prov Gen Hosp, Calgary, AB T2N 2T9, Canada

[13] Royal Victoria Hosp, Montreal, PQ H3A 1A1, Canada

[14] Ottawa Hosp, Ottawa, ON, Canada

[15] St Boniface Gen Hosp, Winnipeg, MB R2H 2A6, Canada

[16] Hop St Luc, CHUM, Montreal, PQ H2X 1P1, Canada

[17] Mt Sinai Hosp, Toronto, ON M5G 1X5, Canada

[18] Royal Univ Hosp, Saskatoon, SK S7N 0W8, Canada

[19] St Josephs Hlth Ctr, London, ON, Canada

[20] McGill Univ, Jewish Gen Hosp, Montreal, PQ H3T 1E2, Canada

[21] Royal Alexandra Hosp, Edmonton, AB, Canada

来源：

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY | 2010年 / 202卷 / 03期

基金：

加拿大健康研究院;

关键词：

preeclampsia; randomized controlled trial; vitamins C and E; VITAMIN-E; OXIDATIVE STRESS; BIRTH-WEIGHT; LIPID-PEROXIDATION; ALPHA-TOCOPHEROL; PREGNANT-WOMEN; HIGH-RISK; SUPPLEMENTATION; HYPERTENSION; PLASMA;

D O I：

10.1016/j.ajog.2010.01.050

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

OBJECTIVE: We sought to investigate whether prenatal vitamin C and E supplementation reduces the incidence of gestational hypertension (GH) and its adverse conditions among high-and low-risk women. STUDY DESIGN: In a multicenter randomized controlled trial, women were stratified by the risk status and assigned to daily treatment (1 g vitamin C and 400 IU vitamin E) or placebo. The primary outcome was GH and its adverse conditions. RESULTS: Of the 2647 women randomized, 2363 were included in the analysis. There was no difference in the risk of GH and its adverse conditions between groups (relative risk, 0.99; 95% confidence interval, 0.78-1.26). However, vitamins C and E increased the risk of fetal loss or perinatal death (nonprespecified) as well as preterm prelabor rupture of membranes. CONCLUSION: Vitamin C and E supplementation did not reduce the rate of preeclampsia or GH, but increased the risk of fetal loss or perinatal death and preterm prelabor rupture of membranes.

引用

页码：239.e1 / 239.e10

页数：10

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