Neonatal alloimmune thrombocytopenia due to an antibody against a labile component of human platelet antigen-3b (Bakb)

被引：19

作者：

Kataoka, S

Kobayashi, H

Chiba, K

Nakamura, M

Shinada, S

Morita, S

Lin, M

Shibata, Y

机构：

[1] Saiseikai Sanjo Hosp, Dept Pediat, Sanjo City, Niigata 9558511, Japan

[2] Niigata Red Cross Blood Ctr, Niigata, Japan

[3] Saitama Red Cross Blood Ctr, Saitama, Japan

[4] Mackay Mem Hosp, Taipei, Taiwan

来源：

TRANSFUSION MEDICINE | 2004年 / 14卷 / 06期

关键词：

HPA-3b; labile component; magnetic mixed passive haemagglutination; neonatal alloimmune thrombocytopenia;

D O I：

10.1111/j.1365-3148.2004.00537.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report the second case of neonatal alloimmune thrombocytopenia due to anti-human platelet antigen (HPA)-3b (Bak(b)) antibody. The infant was severely affected with intracranial haemorrhage. Most importantly, we were able to detect this antibody only by using fresh, unfixed platelets as antigen. This antibody was detectable neither by conventional mixed passive haemagglutination, platelet immunofluorescence test using fixed platelets, nor by monoclonal antigen immobilization of platelet antigen assay using solubilized platelets. We assume that this antibody reacts only with fresh platelets and that the antigen is a labile component of HPA-3b (Bak(b)).

引用

页码：419 / 423

页数：5

共 18 条

[1] BAKA, A NEW PLATELET-SPECIFIC ANTIGEN INVOLVED IN NEONATAL ALLO-IMMUNE THROMBOCYTOPENIA [J].