Large-Pore Mesoporous-Silica-Assisted synthesis of high-performance ZnGa2O4:Cr3+/Sn4+@MSNs multifunctional nanoplatform with optimized optical probe mass ratio and superior residual pore volume for improved bioimaging and drug delivery

被引：37

作者：

Gao, Yi-Fan ^{[1
]}

Zou, Rui ^{[1
,2
]}

Chen, Guang-Feng ^{[1
]}

Liu, Bo-Mei ^{[1
]}

Zhang, Yong ^{[1
]}

Jiao, Ju ^{[1
]}

Wong, Ka-Leung ^{[2
]}

Wang, Jing ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Sun Yatsen Univ, Affiliated Hosp 3,Dept Nucl Med, Minist Educ Key Lab Bioinorgan & Synthet,Sch Chem, Guangzhou 510275, Guangdong, Peoples R China

[2] Hong Kong Baptist Univ, Dept Chem, Kowloon Tong, Hong Kong, Peoples R China

来源：

CHEMICAL ENGINEERING JOURNAL | 2021年 / 420卷 / 420期

基金：

中国国家自然科学基金;

关键词：

Near-infrared; Persistent luminescence; Mesoporous silica; Bioimaging; Drug delivery; PERSISTENT LUMINESCENT NANOPARTICLES; NANOPROBES; NANOPHOSPHORS; AFTERGLOW; CR3+;

D O I：

10.1016/j.cej.2021.130021

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Featured with excellent biocompatibility and background-free biomedical imaging, near infrared persistent luminescence (NIR-PersL) nanomaterials synthesized by mesoporous silica nanoparticles (MSNs) template have captured increasing attentions to be as a tumor theranostic nanoplatform. Unfortunately, many researches in the past decades have mainly focused on bioimaging performance of NIR-PersL nanomaterials themselves but not synergistically on tailoring the pore volume of the MSNs to optimize the drug loading/releasing performance, which greatly limits their potential application in tumor theranostics. In this work, we propose a tailorable largepore mesoporous-silica-assisted synthesis strategy to synthesize a series of ZnGa2O4:Cr3+/Sn4+@MSNs (ZGOCS@MSNs) NIR-PersL nanospheres as nanoplatform. The ZGOCS@MSNs possess average diameters of - 80 nm. More interestingly, the mass ratio of ZGOCS to MSNs (MRZM) increases with the increasing of pore sizes of MSNs and the NIR-PersL performances of ZGOCS@MSNs enhance with the increase of MRZM, suggesting that MRZM plays an important role in optimizing NIR-PersL performance of the nanospheres. In vitro and in vivo NIRPersL imaging further confirm the MRZM-dependent performance enhancement in NIR-PersL nanospheres. More importantly, the employment of large pore MSNs maintains the mesoporous structure of NIR-PersL nanospheres and the residual pore volume of ZnGa2O4:Cr3+/Sn4+@MSNs is high enough and available for efficient drug loading/releasing. Benefited from excellent rechargeable tumor NIR-PersL imaging ability and large residual cavities, ZGOCS@MSNs show high dose (-53%) of loading DOX and exhibit outstanding cancer cell killing efficiency, implying the MRZM also plays an important role in optimizing the drug loading/releasing performance of the nanospheres. In summary, the as-synthesized high performance ZnGa2O4:Cr3+/Sn4+@MSNs bifunctional nanoplatform showcases its great potential for imaging-guided cancer chemotherapy. We expect our work could take the development of NIR-PersL-based theranostic nanoplatforms a step forward.

引用

页数：12